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公开(公告)号：US4593000A
公开(公告)日：1986-06-03
申请号：US688286
申请日：1985-01-07
申请人： Yasuhiro Sumino , Koji Sonoi , Muneharu Doi
发明人： Yasuhiro Sumino , Koji Sonoi , Muneharu Doi
CPC分类号： C12P19/40
摘要： A method of producing guanosine using an adenine-requiring microorganism, in which method the amount of the adenine-containing material to be added to the initial medium is restricted to not more than 50% of the required amount and, after the adenine-containing material added to the initial medium has been consumed almost completely, the remainder of the required amount is added intermittently or continuously.
摘要翻译： 使用需要腺嘌呤的微生物生产鸟苷的方法，其中添加到初始培养基中的含腺嘌呤的材料的量被限制在不超过要求量的50％，并且在含腺嘌呤的材料 添加到初始培养基已经几乎完全消耗，所需量的其余部分间歇地或连续地添加。
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公开(公告)号：US4452889A
公开(公告)日：1984-06-05
申请号：US389459
申请日：1982-06-17
申请人： Koji Sonoi , Yasuhiro Sumino , Muneharu Doi
发明人： Koji Sonoi , Yasuhiro Sumino , Muneharu Doi
CPC分类号： C12P19/40 , Y10S435/813 , Y10S435/832 , Y10S435/839 , Y10S435/84 , Y10S435/843
摘要： A method of producing inosine and/or guanosine comprising cultivating a microorganism in a medium containing a carbohydrate, in which method a carbohydrate is added either continuously or intermittently to the medium when and in the state that the concentration of the carbohydrate in the medium is less than about 1 percent so that the carbohydrate concentration of the medium is maintained below about 1 percent.
摘要翻译： 一种生产肌苷和/或鸟苷的方法，包括在含有碳水化合物的培养基中培养微生物，其中，当培养基中碳水化合物的浓度较低时，以及在培养基中碳水化合物浓度较低的情况下，碳水化合物连续地或间歇地加入到培养基中 超过约1％，使得培养基的碳水化合物浓度保持在约1％以下。
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公开(公告)号：US4578336A
公开(公告)日：1986-03-25
申请号：US444457
申请日：1982-11-24
申请人： Yasuhiro Sumino , Koji Sonoi , Muneharu Doi
发明人： Yasuhiro Sumino , Koji Sonoi , Muneharu Doi
CPC分类号： C12P19/40 , Y10S435/813 , Y10S435/818 , Y10S435/832 , Y10S435/839
摘要： In a fermentation procedure for the production of nucleosides i.e. inosine and/or guanosine using an adenine-requiring microorganism, the fermentation is carried out by allowing a source of adenine to be present in the medium in an excess amount over the amount of adenine that would be conductive to a maximum yield of inosine and/or guanosine in aerobic culture using ordinary air, and cultivating the microorganism while an oxygen-rich gas is bubbled into the medium. Thus, inosine and/or guanosine are accumulated in high yield in the fermentation broth.
摘要翻译： 在使用需要腺嘌呤的微生物生产核苷（即肌苷和/或鸟苷）的发酵方法中，通过使腺嘌呤源以超过腺嘌呤的量存在于培养基中的方式进行发酵， 在使用普通空气的需氧培养中导致肌苷和/或鸟苷的最大产率，并且在富氧气体鼓泡入培养基的同时培养微生物。 因此，在发酵液中以高收率积累肌苷和/或鸟苷。
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