专利检索 ap:("Korea Institute of Ocean Science & Technology" OR "Kiweon Cha") AND inv:"Jurang Woo" 第 1 页

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发明授权
FGF2 polypeptide with improved temperature stability and protease resistance and use thereof 有权

公开(公告)号：US12103953B2

公开(公告)日：2024-10-01

申请号：US17779210

申请日：2020-11-16

申请人： Korea Institute of Ocean Science & Technology , Kiweon Cha

发明人： Jung-Hyun Lee , Hyung-Soon Yim , Young Jun An , Kyeong Won Lee , Ye Eun Jeong , Kiweon Cha , Won Kyu Lee , Jurang Woo

IPC分类号： C07K14/50 , C12N5/0735

CPC分类号： C07K14/50 , C12N5/0606

摘要： Provided is a polypeptide having FGF2 activity and improved temperature stability and protease resistance. The polypeptide includes at least one substitution selected from a substitution of aspartic acid (D) with glutamic acid (E) at position 28, a substitution of cysteine (C) with isoleucine (I) or leucine (L) at position 78, or a substitution of cysteine (C) with isoleucine (I) or tryptophan (W) at position 96 in SEQ ID NO: 1.