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1.发明授权公开(公告)号：US12103953B2
公开(公告)日：2024-10-01
申请号：US17779210
申请日：2020-11-16
发明人： Jung-Hyun Lee , Hyung-Soon Yim , Young Jun An , Kyeong Won Lee , Ye Eun Jeong , Kiweon Cha , Won Kyu Lee , Jurang Woo
IPC分类号： C07K14/50 , C12N5/0735
CPC分类号： C07K14/50 , C12N5/0606
摘要： Provided is a polypeptide having FGF2 activity and improved temperature stability and protease resistance. The polypeptide includes at least one substitution selected from a substitution of aspartic acid (D) with glutamic acid (E) at position 28, a substitution of cysteine (C) with isoleucine (I) or leucine (L) at position 78, or a substitution of cysteine (C) with isoleucine (I) or tryptophan (W) at position 96 in SEQ ID NO: 1.
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2.发明授权公开(公告)号：US07338936B2
公开(公告)日：2008-03-04
申请号：US10971559
申请日：2004-10-22
申请人： David J. Lim , Haa-Yung Lee , Paul Webster , Ali Andalibi , Jian-Dong Li , Tomas Ganz , Kiweon Cha
发明人： David J. Lim , Haa-Yung Lee , Paul Webster , Ali Andalibi , Jian-Dong Li , Tomas Ganz , Kiweon Cha
IPC分类号： A61K38/17 , C07K14/435
CPC分类号： A61K38/1729 , A61K38/40 , A61K38/47 , C12Y302/01017
摘要： The pharmaceutical composition and a method of treatment of infectious diseases, such as otitis media, paranasal sinusitis, labyrinthitis and meningitis are described. The composition comprises EP2E or homologues thereof.
摘要翻译： 描述了药物组合物和治疗感染性疾病如中耳炎，鼻旁窦炎，迷路炎和脑膜炎的方法。 组合物包含EP2E或其同系物。
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3.发明申请USE OF ANTIMICROBIAL PROTEINS AND PEPTIDES FOR THE TREATMENT OF OTITIS MEDIA AND PARANASAL SINUSITIS 审中-公开用于治疗传播媒介和旁观者的抗微生物蛋白质和蛋白质的使用公开(公告)号：US20070207963A1
公开(公告)日：2007-09-06
申请号：US11750542
申请日：2007-05-18
申请人： David Lim , Haa-Yung Lee , Paul Webster , Ali Andalibi , Jian-Dong Li , Tomas Ganz , Kiweon Cha
发明人： David Lim , Haa-Yung Lee , Paul Webster , Ali Andalibi , Jian-Dong Li , Tomas Ganz , Kiweon Cha
IPC分类号： A61K38/16
CPC分类号： A61K38/1729 , A61K38/40 , A61K38/47 , C12Y302/01017
摘要： The pharmaceutical composition and a method of treatment of infectious diseases, such as otitis media, paranasal sinusitis, labyrinthitis and meningitis are described. The composition comprises EP2E or homologues thereof.
摘要翻译： 描述了药物组合物和治疗感染性疾病如中耳炎，鼻旁窦炎，迷路炎和脑膜炎的方法。 组合物包含EP2E或其同系物。
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4.发明授权公开(公告)号：US07985729B2
公开(公告)日：2011-07-26
申请号：US12764852
申请日：2010-04-21
申请人： David J. Lim , Haa-Yung Lee , Paul Webster , Ali Andalibi , Jian-Dong Li , Tomas Ganz , Kiweon Cha
发明人： David J. Lim , Haa-Yung Lee , Paul Webster , Ali Andalibi , Jian-Dong Li , Tomas Ganz , Kiweon Cha
IPC分类号： A61P31/04 , A61K38/17 , C07K14/435
CPC分类号： A61K38/1729 , A61K38/40 , A61K38/47 , C12Y302/01017
摘要： The pharmaceutical composition and a method of treatment of infectious diseases, such as otitis media, paranasal sinusitis, labyrinthitis and meningitis are described. The composition comprises EP2E or homologues thereof.
摘要翻译： 描述了药物组合物和治疗感染性疾病如中耳炎，鼻旁窦炎，迷路炎和脑膜炎的方法。 组合物包含EP2E或其同系物。
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5.发明申请USE OF ANTIMICROBIAL PROTEINS AND PEPTIDES FOR THE TREATMENT OF OTITIS MEDIA AND PARANASAL SINUSITIS 审中-公开用于治疗传播媒介和旁观者的抗微生物蛋白质和蛋白质的使用公开(公告)号：US20090023893A1
公开(公告)日：2009-01-22
申请号：US12174577
申请日：2008-07-16
申请人： David J. Lim , Haa-Yung Lee , Paul Webster , Ali Andalibi , Jian-Dong Li , Tomas Ganz , Kiweon Cha
发明人： David J. Lim , Haa-Yung Lee , Paul Webster , Ali Andalibi , Jian-Dong Li , Tomas Ganz , Kiweon Cha
IPC分类号： C07K14/00
CPC分类号： A61K38/1729 , A61K38/40 , A61K38/47 , C12Y302/01017
摘要： The pharmaceutical composition and a method of treatment of infectious diseases, such as otitis media, paranasal sinusitis, labyrinthitis and meningitis are described. The composition comprises EP2E or homologues thereof.
摘要翻译： 描述了药物组合物和治疗感染性疾病如中耳炎，鼻旁窦炎，迷路炎和脑膜炎的方法。 组合物包含EP2E或其同系物。
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6.发明申请公开(公告)号：US20230076299A1
公开(公告)日：2023-03-09
申请号：US17779210
申请日：2020-11-16
发明人： Jung-Hyun LEE , Hyung-Soon YIM , Young Jun AN , Kyeon Won LEE , Ye Eun JEONG , Kiweon CHA , Won Kyu LEE , Jurang WOO
IPC分类号： C07K14/50 , C12N5/0735
摘要： Provided is a polypeptide having FGF2 activity and improved temperature stability and protease resistance. The polypeptide includes at least one substitution selected from a substitution of aspartic acid (D) with glutamic acid (E) at position 28, a substitution of cysteine (C) with isoleucine (I) or leucine (L) at position 78, or a substitution of cysteine (C) with isoleucine (I) or tryptophan (VV) at position 96 in SEQ ID NO: 1.
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7.发明申请USE OF ANITMICROBIAL PROTEINS AND PEPTIDES FOR THE TREATMENT OF OTITIS MEDIA AND PARANASAL SINUSITIS 失效用于治疗传播媒介和旁观者的抗微生物蛋白质和肽的用途公开(公告)号：US20100204447A1
公开(公告)日：2010-08-12
申请号：US12764852
申请日：2010-04-21
申请人： DAVID J. LIM , HAA-YUNG LEE , PAUL WEBSTER , ALI ANDALIBI , JIAN-DONG LI , TOMAS GANZ , KIWEON CHA
发明人： DAVID J. LIM , HAA-YUNG LEE , PAUL WEBSTER , ALI ANDALIBI , JIAN-DONG LI , TOMAS GANZ , KIWEON CHA
IPC分类号： C07K14/435
CPC分类号： A61K38/1729 , A61K38/40 , A61K38/47 , C12Y302/01017
摘要： The pharmaceutical composition and a method of treatment of infectious diseases, such as otitis media, paranasal sinusitis, labyrinthitis and meningitis are described. The composition comprises EP2E or homologues thereof.
摘要翻译： 描述了药物组合物和治疗感染性疾病如中耳炎，鼻旁窦炎，迷路炎和脑膜炎的方法。 组合物包含EP2E或其同系物。
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8.发明申请公开(公告)号：US20060034820A1
公开(公告)日：2006-02-16
申请号：US10971559
申请日：2004-10-22
申请人： David Lim , Haa-Yung Lee , Paul Webster , Ali Andalibi , Jian-Dong Li , Tomas Ganz , Kiweon Cha
发明人： David Lim , Haa-Yung Lee , Paul Webster , Ali Andalibi , Jian-Dong Li , Tomas Ganz , Kiweon Cha
CPC分类号： A61K38/1729 , A61K38/40 , A61K38/47 , C12Y302/01017
摘要： The pharmaceutical composition and a method of treatment of infectious diseases, such as otitis media, paranasal sinusitis, labyrinthitis and meningitis are described. The composition comprises EP2E or homologues thereof.
摘要翻译： 描述了药物组合物和治疗感染性疾病如中耳炎，鼻旁窦炎，迷路炎和脑膜炎的方法。 组合物包含EP2E或其同系物。
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