公开(公告)号：US20040087633A1

公开(公告)日：2004-05-06

申请号：US10694843

申请日：2003-10-29

Applicant: Korea Institute of Science and Technology

Inventor： Hun Yeong Koh ,  Yong Seo Cho ,  Ae Nim Pae ,  Joo Hwan Cha ,  Hye Yeon Kim ,  Jae Seok Lee ,  Hak Soo Kim ,  Sanghee Kim

IPC: A61K031/433 ,  A61K031/427 ,  A61K031/422 ,  C07D417/14 ,  C07D413/14

CPC classification number: C07D413/10 ,  C07D413/14 ,  C07D417/14

Abstract: A methylidene oxazolidinone compound represented by formula (1) or a pharmaceutically acceptable salt thereof, and a preparation method thereof, showing superior antimicrobial activities against gram-positive germs including resistant strains such as methicillic-resistant staphylococcus aureus and vancomycin-resistant enterococcus: 1

Abstract translation: 由式（1）表示的亚甲基恶唑烷酮化合物或其药学上可接受的盐及其制备方法，对包括抗性菌株如耐甲氧西林金黄色葡萄球菌和万古霉素耐药性肠球菌的革兰氏阳性菌具有优异的抗微生物活性：

公开(公告)号：US20030139464A1

公开(公告)日：2003-07-24

申请号：US10327793

申请日：2002-12-23

Applicant: Korea Institute of Science and Technology

Inventor： Hun Yeong Koh ,  Kyuno Choi II ,  Yong Seo Cho ,  Ae Nim Pae ,  Joo Hwan Cha ,  Ye Sun Han ,  Jong Soo Lee ,  Hong Chul Yun

IPC: A61K031/4035 ,  C07D209/48

CPC classification number: C07D209/48

Abstract: A compound represented by a genera formula (Ia) or (Ib) and a stereo-selective preparation method thereof using a carbonyl reductase which is separated from Kluyveromyces marxianus. The compound can be prepared by reduction of substituted null-keto ester and can be used as an intermediate in preparing null-lactam group antibiotics. 1

Abstract translation: 由式（Ia）或（Ib）表示的化合物及其使用从马克斯克鲁维酵母分离的羰基还原酶的立体选择性制备方法。 该化合物可以通过还原取代的β-酮酯制备，并且可以用作制备β-内酰胺类抗生素的中间体。