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159 条记录 (耗时 0.044 秒)

    Tgf-beta superfamily production/secretion promoter
    6.
    发明申请
    Tgf-beta superfamily production/secretion promoter 失效
    Tgf-β超家族生产/分泌启动子

    公开(公告)号：US20040142988A1

    公开(公告)日：2004-07-22

    申请号：US10480849

    申请日：2003-12-16

    发明人： Yasuo Sugiyama ,  Masatoshi Hazama ,  Asae Shintani

    IPC分类号： A61K031/427 ,  A61K031/422 ,  A61K031/4178

    CPC分类号： A61K31/422

    摘要： The present invention provides a TGF-null superfamily production/secretion promoter comprising a compound represented by the formula 1 wherein R1 is a halogen atom, an optionally substituted heterocyclic group, an optionally substituted hydroxy group, an optionally substituted thiol group or an optionally substituted amino group; A is an optionally substituted acyl group, an optionally substituted heterocyclic group, an optionally substituted hydroxy group or an optionally esterified or amidated carboxyl group; B is an optionally substituted aromatic group; X is an oxygen atom, a sulfur atom or an optionally substituted nitrogen atom; and Y is a divalent hydrocarbon group or heterocyclic group, or a salt thereof or a prodrug thereof, which is useful as an agent for the prophylaxis or treatment of dysautonomia, bladder dysfunction, hearing impairment, bone disease and the like.

    摘要翻译： 本发明提供了一种TGF-β超家族产生/分泌促进剂，其包含下式表示的化合物其中R 1为卤素原子，任选取代的杂环基，任选取代的羟基，任选取代的硫醇基或任选地 取代氨基; A是任选取代的酰基，任选取代的杂环基，任选取代的羟基或任选酯化或酰胺化的羧基; B是任选取代的芳基; X是氧原子，硫原子或任选取代的氮原子; Y是二价烃基或杂环基，或其盐或其前药，其可用作预防或治疗自主神经功能障碍，膀胱功能障碍，听力障碍，骨病等。

    Dihydronaphthalene derivative compounds and drugs containing these compounds as the active ingredient
    7.
    发明申请
    Dihydronaphthalene derivative compounds and drugs containing these compounds as the active ingredient 失效
    二氢萘衍生物化合物和含有这些化合物作为活性成分的药物

    公开(公告)号：US20040138213A1

    公开(公告)日：2004-07-15

    申请号：US10451679

    申请日：2004-02-09

    发明人： Hisao Tajima ,  Yoshisuke Nakayama ,  Daikichi Fukushima

    IPC分类号： A61K031/541 ,  A61K031/5377 ,  A61K031/496 ,  A61K031/454 ,  A61K031/426 ,  A61K031/422

    CPC分类号： C07D407/04 ,  C07D263/32 ,  C07D277/40 ,  C07D277/42 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04

    摘要： A compound of formula (I) 1 (wherein all symbols are as defined in the specification) and salt thereof, and peroxisome proliferator activated receptor regulator comprising thereof as active ingredient. Because a compound of formula (I) have an activity of regulating peroxisome proliferator activated receptor regulator, the compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or treatment agent for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or syndrome X.

    摘要翻译： 式（I）的化合物（其中所有符号如说明书中所定义）及其盐，以及其包含作为活性成分的过氧化物酶体增殖物激活受体调节剂。 由于式（I）化合物具有调节过氧化物酶体增殖物激活受体调节剂的活性，式（I）化合物可用作降血糖剂，​​降血脂剂，与代谢紊乱相关的疾病的预防和/或治疗剂（ 糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症等），高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食，冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低 药物和缓解糖尿病或综合征X危险因素的药物。