公开(公告)号：US20230025531A1

公开(公告)日：2023-01-26

申请号：US17367254

申请日：2021-07-02

Applicant: Korea Research Institute of Chemical Technology

Inventor： Myung-Ae BAE ,  Dae-Seop SHIN ,  Jung Yoon YANG ,  Kyu Seok HWANG ,  Seong Soon KIM ,  Byung Hoi LEE ,  Ki Young KIM ,  Won Hoon JUNG ,  Jae Chun WOO

IPC: A61K31/472 ,  A61K9/00 ,  A61P17/00 ,  A61K31/47 ,  A61P29/00 ,  A61P1/16

Abstract: The present invention relates to a novel isoquinoline derivative, a preparing method thereof, and a pharmaceutical composition for preventing or treating autophagy related diseases containing the same as an active ingredient. The novel isoquinoline furanone derivative according to the present invention is capable of regulating autophagy activity, and thus, by using this derivative as an active ingredient, there is a useful effect that can be used as a pharmaceutical composition for preventing or treating autophagy-related diseases such as neurodegenerative diseases, cancer, metabolic diseases, inflammatory diseases or melanogenesis-related diseases, a health functional food composition for ameliorating thereof, or a cosmetic composition with a whitening function.