公开(公告)号：US20150329504A1

公开(公告)日：2015-11-19

申请号：US14396663

申请日：2013-04-25

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  HANDOK PHARMACEUTICALS CO., LTD.

Inventor： Jin Hee AHN ,  H.S. PAGIRE ,  Sal Dal RHEE ,  Ki Young KIM ,  Won Hoon JUNG ,  Myung-Ae BAE ,  Jin Sook SONG ,  Kwang-Rok KIM ,  Hyun Jung KWAK

IPC: C07D263/34 ,  A61K31/421 ,  C07D231/14 ,  A61K31/415 ,  C07C271/22 ,  A61K31/167 ,  C07C237/12 ,  A61K31/216 ,  C07D231/12 ,  C07D209/42 ,  A61K31/403 ,  C07C237/22 ,  A61K45/06 ,  A61K31/27

CPC classification number: C07D213/82 ,  A61K31/167 ,  A61K31/216 ,  A61K31/27 ,  A61K31/403 ,  A61K31/415 ,  A61K31/421 ,  A61K45/06 ,  C07B2200/07 ,  C07C237/04 ,  C07C237/12 ,  C07C237/22 ,  C07C271/22 ,  C07C2601/14 ,  C07D209/20 ,  C07D209/42 ,  C07D213/56 ,  C07D231/12 ,  C07D231/14 ,  C07D239/26 ,  C07D261/08 ,  C07D261/10 ,  C07D263/32 ,  C07D263/34 ,  C07D271/06 ,  C07D277/30 ,  C07D277/56 ,  C07D417/12

Abstract: The present invention relates to a beta-alanine derivative, pharmaceutically acceptable salts thereof, and a pharmaceutical composition including the same as an active ingredient. The novel beta-alanine derivative and pharmaceutically acceptable salts thereof according to the present invention may effectively inhibit the activity of DGAT1, which is an enzyme serving as a catalyst in the final step of the synthesis of neutral lipids, to thereby be effectively used as a pharmaceutical composition for preventing or treating various lipid metabolism-related disorders selected from the group consisting of obesity, dyslipidemia, fatty liver, insulin resistance syndrome, and hepatitis.

Abstract translation: 本发明涉及β-丙氨酸衍生物，其药学上可接受的盐，以及包含其作为活性成分的药物组合物。 根据本发明的新型β-丙氨酸衍生物及其药学上可接受的盐可有效抑制DGAT1的活性，DGAT1作为在中性脂质合成的最后步骤中用作催化剂的酶，从而有效地用作 用于预防或治疗选自肥胖，血脂异常，脂肪肝，胰岛素抵抗综合征和肝炎的各种脂质代谢相关疾病的药物组合物。

公开(公告)号：US20230025531A1

公开(公告)日：2023-01-26

申请号：US17367254

申请日：2021-07-02

Applicant: Korea Research Institute of Chemical Technology

Inventor： Myung-Ae BAE ,  Dae-Seop SHIN ,  Jung Yoon YANG ,  Kyu Seok HWANG ,  Seong Soon KIM ,  Byung Hoi LEE ,  Ki Young KIM ,  Won Hoon JUNG ,  Jae Chun WOO

IPC: A61K31/472 ,  A61K9/00 ,  A61P17/00 ,  A61K31/47 ,  A61P29/00 ,  A61P1/16

Abstract: The present invention relates to a novel isoquinoline derivative, a preparing method thereof, and a pharmaceutical composition for preventing or treating autophagy related diseases containing the same as an active ingredient. The novel isoquinoline furanone derivative according to the present invention is capable of regulating autophagy activity, and thus, by using this derivative as an active ingredient, there is a useful effect that can be used as a pharmaceutical composition for preventing or treating autophagy-related diseases such as neurodegenerative diseases, cancer, metabolic diseases, inflammatory diseases or melanogenesis-related diseases, a health functional food composition for ameliorating thereof, or a cosmetic composition with a whitening function.

公开(公告)号：US20130123297A1

公开(公告)日：2013-05-16

申请号：US13734348

申请日：2013-01-04

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Nak Jeong KIM ,  Myung-Ae BAE ,  Sung-Eun YOO ,  Namsook KANG ,  Jung Nyoung HEO ,  Kyu Yang YI ,  Jee Hee SUH ,  Sung Youn CHANG ,  Eun Sook HWANG ,  Jeong-Ho HONG

IPC: C07D471/04 ,  C07D403/10

CPC classification number: C07D471/04 ,  A61K31/437 ,  C07D403/10

Abstract: A pharmaceutical composition comprising a phenyltetrazole derivative of formula (I) or a pharmaceutical acceptable salt thereof is effective in preventing or treating osteoporosis, obesity, diabetes, or hyperlipidemia, by regulating protein TAZ. wherein, A is ethyl or n-butyl; R1 is methyl, —CH2OH, —CO2CH3, —CH2F, —CH(OCH3)2, —CH2OC(═O)CH3, styryl or —CH2OCH2SCH3; R2 is H, Br, —CO2CH3, phenyl, pyridin-2-yl, pyridin-3-yl, or styryl; R3 is H or methyl; X is CH or N; and P is H or —CH(CH3)OCH2CH3.

Abstract translation: 通过调节蛋白质TAZ，包含式（I）的苯基四唑衍生物或其药学上可接受的盐的药物组合物可有效预防或治疗骨质疏松症，肥胖症，糖尿病或高脂血症。 其中A为乙基或正丁基; R1是甲基，-CH2OH，-CO2CH3，-CH2F，-CH（OCH3）2，-CH2OC（= O）CH3，苯乙烯基或-CH2OCH2SCH3; R 2是H，Br，-CO 2 CH 3，苯基，吡啶-2-基，吡啶-3-基或苯乙烯基; R3是H或甲基; X是CH或N; 并且P是H或-CH（CH 3）OCH 2 CH 3。