公开(公告)号：US07713942B2

公开(公告)日：2010-05-11

申请号：US10114957

申请日：2002-04-04

申请人： Kristian Dalsgaard ,  Nikolai Søren Kirkby

发明人： Kristian Dalsgaard ,  Nikolai Søren Kirkby

IPC分类号： A01N43/04 ,  A61K31/70 ,  A61K9/14 ,  A61K45/00 ,  A61K47/44

CPC分类号： A61K39/39 ,  A61K48/00 ,  C12N15/87

摘要： The present invention pertains to complexes comprising sterols and saponins. The complexes are capable of binding a genetic determinant including a polynucleotide. The complexes may further comprise a lipophilic moiety, optionally a lipophilic moiety comprising a contacting group and/or a targeting ligand, and/or a saccharide moiety. The complexes may further comprise an immunogenic determinant and/or an antigenic determinant and/or a medicament and/or a diagnostic compound. The complexes may in even further embodiments be encapsulated by an encapsulation agent including a biodegradable microsphere. The present invention also pertains to pharmaceutical compositions and methods of treatment of an individual by therapy and/or surgery, methods of cosmetic treatment, and diagnostic methods practised on the human or animal body.

摘要翻译： 本发明涉及包含甾醇和皂苷的复合物。 复合物能够结合包括多核苷酸的遗传决定簇。 所述配合物还可包含亲脂部分，任选包含接触基团和/或靶向配体和/或糖部分的亲油部分。 复合物还可包含免疫原性决定簇和/或抗原决定簇和/或药物和/或诊断化合物。 复合物在甚至进一步的实施方案中可以通过包括可生物降解的微球的包封剂来包封。 本发明还涉及通过治疗和/或手术治疗个体的药物组合物和方法，在人或动物体上实施的美容治疗方法和诊断方法。