中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

5 records (took 0.017 seconds)

    Nitric oxide-producing hydrogel materials
    4.
    发明授权
    Nitric oxide-producing hydrogel materials 失效

    公开(公告)号：US07052711B2

    公开(公告)日：2006-05-30

    申请号：US10129418

    申请日：2001-09-04

    Applicant: Jennifer L. West ,  Kristyn Simcha Masters

    Inventor： Jennifer L. West ,  Kristyn Simcha Masters

    IPC: A61F2/02 ,  A61K9/14

    CPC classification number: A61K9/06 ,  A61F2/82 ,  A61K9/0019 ,  A61K31/00 ,  A61K33/00 ,  A61K47/58 ,  A61K47/60 ,  A61K47/6903

    Abstract: Hydrogels releasing or producing NO, most preferably polymerizable biodegradable hydrogels capable of releasing physiological amounts of NO for prolonged periods of time, are applied to sites on or in a patient in need of treatment thereof for disorders such as restenosis, thrombosis, asthma, wound healing, arthritis, penile erectile dysfunction or other conditions where NO plays a significant role. The polymeric materials can be formed into films, coatings, or microparticles for application to medical devices, such as stents, vascular grafts and catheters. The polymeric materials can also be applied directly to biological tissues and can be polymerized in situ. The hydrogels are formed of macromers, which preferably include biodegradable regions, and have bound thereto groups that are released in situ to elevate or otherwise modulate NO levels at the site where treatment is needed. The macromers can form a homo or hetero-dispersion or solution, which is polymerized to form a hydrogel material, that in the latter case can be a semi-interpenetrating network or interpenetrating network. Compounds to be released can be physically entrapped, covalently or ionically bound to macromer, or actually form a part of the polymeric material. The hydrogel can be formed by ionic and/or covalent crosslinking. Other active agents, including therapeutic, prophylactic, or diagnostic agents, can also be included within the polymeric material.

    Nitric oxide-producing hydrogel materials
    5.
    发明授权
    Nitric oxide-producing hydrogel materials 有权
    产生一氧化氮的水凝胶材料

    公开(公告)号：US07651697B2

    公开(公告)日：2010-01-26

    申请号：US11281242

    申请日：2005-11-17

    Applicant: Jennifer L. West ,  Kristyn Simcha Masters

    Inventor： Jennifer L. West ,  Kristyn Simcha Masters

    IPC: A61F2/02

    CPC classification number: A61K9/06 ,  A61F2/82 ,  A61K9/0019 ,  A61K31/00 ,  A61K33/00 ,  A61K47/58 ,  A61K47/60 ,  A61K47/6903

    Abstract: Hydrogels releasing or producing NO, most preferably polymerizable biodegradable hydrogels capable of releasing physiological amounts of NO for prolonged periods of time, are applied to sites on or in a patient in need of treatment thereof for disorders such as restenosis, thrombosis, asthma, wound healing, arthritis, penile erectile dysfunction or other conditions where NO plays a significant role. The polymeric materials can be formed into films, coatings, or microparticles for application to medical devices, such as stents, vascular grafts and catheters. The polymeric materials can also be applied directly to biological tissues and can be polymerized in situ. The hydrogels are formed of macromers, which preferably include biodegradable regions, and have bound thereto groups that are released in situ to elevate or otherwise modulate NO levels at the site where treatment is needed. The macromers can form a homo or hetero-dispersion or solution, which is polymerized to form a hydrogel material, that in the latter case can be a semi-interpenetrating network or interpenetrating network. Compounds to be released can be physically entrapped, covalently or ionically bound to macromer, or actually form a part of the polymeric material. The hydrogel can be formed by ionic and/or covalent crosslinking. Other active agents, including therapeutic, prophylactic, or diagnostic agents, can also be included within the polymeric material.

    Abstract translation: 释放或产生NO，最优选能够长时间释放生理量的NO的可聚合的可生物降解的水凝胶的水凝胶被施用于需要治疗的患者或患者的位置，例如再狭窄，血栓形成，哮喘，伤口愈合 ，关节炎，阴茎勃起功能障碍或其他NO起重要作用的病症。 聚合物材料可以形成膜，涂层或微粒，用于医疗装置，例如支架，血管移植物和导管。 聚合物材料也可以直接应用于生物组织，并且可以原位聚合。 水凝胶由大分子单体形成，其优选包括可生物降解的区域，并且与原位释放的基团结合以在需要治疗的部位升高或以其他方式调节NO水平。 大分子单体可以形成均聚或异质分散体或溶液，其被聚合以形成水凝胶材料，在后一种情况下可以是半互穿网络或互穿网络。 待释放的化合物可以被物理截留，共价或离子键结合到大分子单体上，或实际上形成聚合物材料的一部分。 水凝胶可以通过离子和/或共价交联形成。 其它活性剂，包括治疗剂，预防剂或诊断剂也可以包括在聚合物材料内。

Patent Agency Ranking