公开(公告)号：US20240050501A1

公开(公告)日：2024-02-15

申请号：US18187797

申请日：2023-03-22

Applicant: Kun-Lin Yang

Inventor： Kun-Lin Yang ,  Tzu-Yang Yang ,  Tzu-Chi Yang ,  Tzu-Yi Yang

IPC: A61K36/07 ,  A23L31/00 ,  C12N1/14

CPC classification number: A61K36/07 ,  A23L31/00 ,  C12N1/14

Abstract: The invention discloses a method for forming a fungi fermentation product containing N-acetylglucosamine. The fungi fermentation product containing N-acetylglucosamine can convert cancer cells into normal cells through a mesenchymal epithelial transition mechanism. The method uses fungi as a starting material which together with a Cordyceps-related fungus is fermented to form a fermentation product which induces a mesenchymal epithelial transition to convert cancer cells into normal cells. The fungi cell wall contains chitin. The fermentation liquid is produced by fermentation of Cordyceps with chitin as the substrate. The main product is N-acetylglucosamine confirmed by an HPLC analysis. According to the experimental data, the fermentation product of N-acetylglucosamine converts cancer cells into epithelial cells that contain E-cadherin and has a square shape. Thus, it is proved that the fermented substance converts cancer cells into normal cells through induction of the mesenchymal epithelial transition mechanism.