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    Methods and compositions associated with administration of an extract of Ganoderma lucidum
    1.
    发明授权
    Methods and compositions associated with administration of an extract of Ganoderma lucidum 有权
    与灵芝提取物的给药相关的方法和组合物

    公开(公告)号：US07687064B2

    公开(公告)日：2010-03-30

    申请号：US11534204

    申请日：2006-09-21

    申请人： Kuo-Feng Hua ,  Hsien-Yeh Hsu ,  Chi-Huey Wong

    发明人： Kuo-Feng Hua ,  Hsien-Yeh Hsu ,  Chi-Huey Wong

    IPC分类号： A61K36/06 ,  A61K9/00 ,  A61K47/00 ,  A23K1/17

    CPC分类号： A61K36/074

    摘要： The present disclosure provides methods for increasing the lipopolysaccharide-induced secretion of IL-1 by macrophages, for increasing serum levels of IL-1 in a mammal, for increasing the serum level of IL-1 receptor antagonist (IL-1Ra) in a mammal, for increasing the secretion of IL-1 by a monocyte, for increasing the secretion of IL-1Ra by a monocyte, for increasing the secretion of IL-1Ra by a macrophage, for increasing expression of TLR4 on the surface of a macrophage, for increasing expression of CD14 on the surface of macrophage, for increasing the uptake and clearance of lipopolysaccharide (LPS) by a LPS-stimulated macrophage, and for increasing lipopolysaccharide (LPS)-stimulated activation of at least one of ERK, JNK, and p38 in a macrophage. The methods of the disclosure involve the administration to mammals and immune cells of a fucose-containing glycoprotein fraction from Ganoderma lucidum.

    摘要翻译： 本公开提供了增加脂多糖诱导的巨噬细胞分泌IL-1的方法，用于增加哺乳动物中IL-1的血清水平，以增加哺乳动物中IL-1受体拮抗剂（IL-1Ra）的血清水平 用于增加单核细胞分泌IL-1，增加单核细胞分泌IL-1Ra，增加巨噬细胞分泌IL-1Ra，增加巨噬细胞表面TLR4的表达，为 增加巨噬细胞表面CD14的表达，增加LPS刺激的巨噬细胞对脂多糖（LPS）的吸收和清除，并增加脂多糖（​​LPS）刺激ERK，JNK和p38中的至少一种的活化 巨噬细胞 本公开的方法涉及从灵芝向哺乳动物和免疫细胞施用含岩藻糖的糖蛋白部分。

    METHODS AND COMPOSITIONS ASSOCIATED WITH ADMINISTRATION OF AN EXTRACT OF GANODERMA LUCIDUM
    2.
    发明申请
    METHODS AND COMPOSITIONS ASSOCIATED WITH ADMINISTRATION OF AN EXTRACT OF GANODERMA LUCIDUM 有权
    与甘草提取物相关的方法和组合物

    公开(公告)号：US20070105814A1

    公开(公告)日：2007-05-10

    申请号：US11534204

    申请日：2006-09-21

    申请人： Kuo-Feng Hua ,  Hsien-Yeh Hsu ,  Chi-Huey Wong

    发明人： Kuo-Feng Hua ,  Hsien-Yeh Hsu ,  Chi-Huey Wong

    IPC分类号： A61K31/715 ,  A01N43/04

    CPC分类号： A61K36/074

    摘要： The present disclosure provides methods for increasing the lipopolysaccharide-induced secretion of IL-1 by macrophages, for increasing serum levels of IL-1 in a mammal, for increasing the serum level of IL-1 receptor antagonist (IL-1Ra) in a mammal, for increasing the secretion of IL-1 by a monocyte, for increasing the secretion of IL-1Ra by a monocyte, for increasing the secretion of IL-1Ra by a macrophage, for increasing expression of TLR4 on the surface of a macrophage, for increasing expression of CD14 on the surface of macrophage, for increasing the uptake and clearance of lipopolysaccharide (LPS) by a LPS-stimulated macrophage, and for increasing lipopolysaccharide (LPS)-stimulated activation of at least one of ERK, JNK, and p38 in a macrophage. The methods of the disclosure involve the administration to mammals and immune cells of a fucose-containing glycoprotein fraction from Ganoderma lucidum.

    摘要翻译： 本公开提供了增加脂多糖诱导的巨噬细胞分泌IL-1的方法，用于增加哺乳动物中IL-1的血清水平，以增加哺乳动物中IL-1受体拮抗剂（IL-1Ra）的血清水平 用于增加单核细胞分泌IL-1，增加单核细胞分泌IL-1Ra，增加巨噬细胞分泌IL-1Ra，增加巨噬细胞表面TLR4的表达，为 增加巨噬细胞表面CD14的表达，增加LPS刺激的巨噬细胞对脂多糖（LPS）的吸收和清除，并增加脂多糖（​​LPS）刺激ERK，JNK和p38中的至少一种的活化 巨噬细胞 本公开的方法涉及从灵芝向哺乳动物和免疫细胞施用含岩藻糖的糖蛋白部分。