公开(公告)号：US10358656B2

公开(公告)日：2019-07-23

申请号：US15872594

申请日：2018-01-16

申请人： Kuros Biosciences AG

发明人： Matthias Kinzler ,  Karl Proba

IPC分类号： C12N15/117 ,  C12N7/00 ,  C07H21/04 ,  C12N15/86 ,  A61K39/00

摘要： The invention provides processes for the producing compositions comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle. The invention further provides processes for producing nucleotide compositions comprising oligonucleotides suitable to be used in the processes mentioned before. The invention further provides nucleotide compositions obtainable by the processes of the invention and uses thereof. The invention further provides compositions comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, wherein said compositions are obtainable by the processes of the invention and wherein said compositions preferably comprises a purity of at least 98%, most preferably of at least 99%.

公开(公告)号：US09902972B2

公开(公告)日：2018-02-27

申请号：US13945708

申请日：2013-07-18

申请人： Kuros Biosciences AG

发明人： Matthias Kinzler ,  Karl Proba

IPC分类号： C12N7/00 ,  C12N15/117 ,  C12N15/86 ,  A61K39/00

CPC分类号： C12N15/86 ,  A61K2039/5258 ,  C12N7/00 ,  C12N15/117 ,  C12N2310/17 ,  C12N2320/32 ,  C12N2795/00034 ,  C12N2795/18122 ,  C12N2795/18123

摘要： The invention provides processes for the producing compositions comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle. The invention further provides processes for producing nucleotide compositions comprising oligonucleotides suitable to be used in the processes mentioned before. The invention further provides nucleotide compositions obtainable by the processes of the invention and uses thereof. The invention further provides compositions comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, wherein said compositions are obtainable by the processes of the invention and wherein said compositions preferably comprises a purity of at least 98%, most preferably of at least 99%.