公开(公告)号：US20120065242A1

公开(公告)日：2012-03-15

申请号：US12905212

申请日：2010-10-15

申请人： Kwang Meyung KIM ,  Ick Chan KWON ,  Kuiwon CHOI ,  Myung Sook HUH ,  Seung Young LEE ,  So Jin LEE

发明人： Kwang Meyung KIM ,  Ick Chan KWON ,  Kuiwon CHOI ,  Myung Sook HUH ,  Seung Young LEE ,  So Jin LEE

IPC分类号： A61K31/713 ,  A61P35/00 ,  C07H21/04 ,  B82Y5/00

CPC分类号： A61K47/4823 ,  A61K47/61 ,  A61K47/6939 ,  C12N15/111 ,  C12N15/87 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/32

摘要： Disclosed is a polymer-siRNA delivery carrier in which a siRNA is combined with a polymer and the use thereof. More specifically, there is disclosed a stable in vivo polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time and the use thereof.The polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time has a high siRNA deliver efficiency to a target portion in vivo. Hence, according to the polymer-siRNA binder, the siRNA for treatment can be effectively delivered to a target portion such as in vivo cancer tissue, and the like even with administration of a relatively low concentration, and thus widely used for the treatment of various kinds of diseases.

摘要翻译： 公开了将siRNA与聚合物组合的聚合物-siRNA递送载体及其用途。 更具体地，公开了一种稳定的体内聚合物-siRNA递送载体，其中通过使用电荷相互作用和可生物降解的共价键在同一时间将聚合物和siRNA组合起来，以及其用途。 通过使用电荷相互作用和可生物降解的共价键合将聚合物和siRNA组合的聚合物-siRNA递送载体在体内对目标部分具有高的siRNA递送效率。 因此，根据聚合物-siRNA粘合剂，即使施用相对低的浓度，也可以将治疗用siRNA有效地输送到诸如体内癌组织等目标部位，广泛用于各种治疗 各种疾病

公开(公告)号：US20120083455A1

公开(公告)日：2012-04-05

申请号：US13245180

申请日：2011-09-26

申请人： Kwangmeyung KIM ,  Ick Chan KWON ,  Kuiwon CHOI ,  In Chan YOUN ,  Myung Sook HUH ,  Sojin LEE

发明人： Kwangmeyung KIM ,  Ick Chan KWON ,  Kuiwon CHOI ,  In Chan YOUN ,  Myung Sook HUH ,  Sojin LEE

IPC分类号： A61K38/38 ,  A61P35/00 ,  C07K14/765

CPC分类号： C12N15/111 ,  A61K47/643 ,  C12N2320/32

摘要： Disclosed are a human serum albumin-siRNA carrier system having siRNA bound to human serum albumin and a user thereof, and especially, human serum albumin-siRNA carrier system, which has a biodegradable covalent bond between human serum albumin polymer and siRNA and is stable in a living body, and a user thereof.The human serum albumin-siRNA carrier system having the biodegradable covalent bond between the human serum albumin and the siRNA exhibits high siRNA delivery efficiency to a target site in the living body. Therefore, the human serum albumin-siRNA carrier system may allow siRNA for therapy to be efficiently delivered to a target site such as cancer tissues in the living body even by being administrated in a relatively low concentration, which may result in a wide use for therapies of various diseases.

摘要翻译： 公开了具有与人血清白蛋白结合的siRNA及其使用者的人血清白蛋白-siRNA载体体系，特别是人血清白蛋白-siRNA载体体系，其在人血清白蛋白聚合物和siRNA之间具有可生物降解的共价键，并且在 生物体及其使用者。 在人体血清白蛋白和siRNA之间具有可生物降解的共价键的人血清白蛋白-siRNA载体体系对生物体中的靶位点显示出高的siRNA递送效率。 因此，人体血清白蛋白-siRNA载体体系可以使siRNA治疗有效地递送到目标部位如生物体中的癌组织，甚至通过以相对低的浓度施用，这可能导致广泛用于治疗 的各种疾病。