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1.发明申请Lectin protein prepared from maackia fauriei, process for preparing the same and the use thereof 有权由麦草制备的凝集素蛋白，其制备方法及其用途公开(公告)号：US20050084903A1
公开(公告)日：2005-04-21
申请号：US10478370
申请日：2002-05-14
申请人： Ha-Hyung Kim , Bum-Soo Kim , Kwang-Hoon Kong
发明人： Ha-Hyung Kim , Bum-Soo Kim , Kwang-Hoon Kong
IPC分类号： A61K38/00 , C07K14/42 , G01N33/53 , A61K38/16 , C07K14/415
摘要： The present invention relates to a lectin protein, designated MFA isolated and purified from the bark of the Korean legume Maackia fauriei, process for preparing the same and the use thereof. This protein can be used as reagents in the study of carbohydrate binding proteins as well as to examine the distribution of N-acetylneuraminic acid in cancer cells owing to its capability that specifically recognizes N-acetylneuraminic acid which plays important structural and functional roles in the expressions of various cells or oligosaccharide terminal residue of glycoconjugates, and, in addition, used as an anti-cancer drug in view of its anti-proliferation effect against various cancers such as breast cancer, melanoma, hepatoma, etc.
摘要翻译： 本发明涉及一种从韩国豆科马鞭草的树皮分离和纯化的称为MFA的凝集素蛋白，其制备方法及其用途。 该蛋白质可用作碳水化合物结合蛋白的研究中的试剂，也可用于检查N-乙酰神经氨酸在癌细胞中的分布，因为其能够特异性识别N-乙酰神经氨酸，其在表达中起重要的结构和功能作用 的糖缀合物的各种细胞或寡糖末端残基，另外，鉴于其对各种癌症如乳腺癌，黑素瘤，肝癌等的抗增殖作用，另外用作抗癌药物。
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2.发明申请Transmembrane domain removed recombinant human tyrosinase and method of producing the same 审中-公开跨膜结构域去除重组人酪氨酸酶及其制备方法公开(公告)号：US20080124758A1
公开(公告)日：2008-05-29
申请号：US11714839
申请日：2007-03-07
申请人： Kwang-Hoon Kong
发明人： Kwang-Hoon Kong
CPC分类号： C12Y203/02002 , A61K39/00 , C12N9/104
摘要： Disclosed are recombinant human tyrosinase, which the transmembrane domain of human tyrosinase is removed and a method of producing the same. The method includes expressing human tyrosinase gene, which C-terminal transmembrane domain of human tyrosinase is removed, and separating and purifying the expressed recombinant human tyrosinase. The method according to the present invention have effects on mass-producing the recombinant human tyrosinase having a good enzyme activity without forming insoluble inclusion body, a simple purifying process and a improved purifying yield.
摘要翻译： 公开了重组人酪氨酸酶，其中除去人酪氨酸酶的跨膜结构域及其制备方法。 该方法包括表达人酪氨酸酶基因，其被去除人酪氨酸酶的C末端跨膜结构域，并分离和纯化表达的重组人酪氨酸酶。 根据本发明的方法具有在不形成不溶性包涵体的情况下批量生产具有良好酶活性的重组人酪氨酸酶的作用，简单的纯化方法和提高的纯化产率。
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3.发明授权Lectin protein prepared from Maackia fauriei, process for preparing the same and the use thereof 有权由麦草制备的凝集素蛋白，其制备方法及其用途公开(公告)号：US07045300B2
公开(公告)日：2006-05-16
申请号：US10478370
申请日：2002-05-14
申请人： Ha-Hyung Kim , Bum-Soo Kim , Kwang-Hoon Kong
发明人： Ha-Hyung Kim , Bum-Soo Kim , Kwang-Hoon Kong
IPC分类号： G01N33/53 , A61K38/16 , C07K14/415
摘要： The present invention relates to a lectin protein, designated MFA isolated and purified from the bark of the Korean legume Maackia fauriei, process for preparing the same and the use thereof. This protein can be used as reagents in the study of carbohydrate binding proteins as well as to examine the distribution of N-acetylneuraminic acid in cancer cells owing to its capability that specifically recognizes N-acetylneuraminic acid which plays important structural and functional roles in the expressions of various cells or oligosaccharide terminal residue of glycoconjugates, and, in addition, used as an anti-cancer drug in view of its anti-proliferation effect against various cancers such as breast cancer, melanoma, hepatoma, etc.
摘要翻译： 本发明涉及一种从韩国豆科马鞭草的树皮分离和纯化的称为MFA的凝集素蛋白，其制备方法及其用途。 该蛋白质可用作碳水化合物结合蛋白的研究中的试剂，也可用于检查N-乙酰神经氨酸在癌细胞中的分布，因为其能够特异性识别N-乙酰神经氨酸，其在表达中起重要的结构和功能作用 的糖缀合物的各种细胞或寡糖末端残基，另外，鉴于其对各种癌症如乳腺癌，黑素瘤，肝癌等的抗增殖作用，另外用作抗癌药物。
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