公开(公告)号：US08735439B2

公开(公告)日：2014-05-27

申请号：US12594186

申请日：2009-04-29

申请人： Kye Shin Park ,  Eun Hee Lee ,  Hyo Jun Kim

发明人： Kye Shin Park ,  Eun Hee Lee ,  Hyo Jun Kim

IPC分类号： C07D487/22

CPC分类号： C07D487/22 ,  A61K41/0071 ,  A61K47/551 ,  C07D519/00

摘要： The present invention relates to a novel chlorin e6-folic acid conjugate, a preparation method thereof, and a pharmaceutical composition for the treatment of cancer comprising the same, and more particularly, to a novel compound prepared by linking chlorin e6 to folic acid, which effectively produces singlet oxygen in various media and has much better tumor selectivity than the known porphyrin-based photosensitizers, thereby being used effectively in photodynamic therapy for malignant tumors, a preparation method thereof, and a pharmaceutical composition for photodynamic treatment of solid tumors comprising the compound as an active ingredient.

摘要翻译： 本发明涉及一种新的二氢卟吩e6-叶酸结合物，其制备方法和用于治疗癌症的药物组合物，特别涉及通过将二氢卟酚e6连接到叶酸而制备的新型化合物，其中 有效地在各种培养基中产生单线态氧，并且具有比已知的基于卟啉的光敏剂更好的肿瘤选择性，从而有效地用于恶性肿瘤的光动力学治疗，其制备方法和用于光动力治疗实体瘤的药物组合物，包括化合物 作为活性成分。

公开(公告)号：US20120059018A1

公开(公告)日：2012-03-08

申请号：US12594186

申请日：2009-04-29

申请人： Kye Shin Park ,  Eun Hee Lee ,  Hyo Jun Kim

发明人： Kye Shin Park ,  Eun Hee Lee ,  Hyo Jun Kim

IPC分类号： A61K31/519 ,  A61P35/00 ,  C07D487/22

CPC分类号： C07D487/22 ,  A61K41/0071 ,  A61K47/551 ,  C07D519/00

摘要： The present invention relates to a novel chlorin e6-folic acid conjugate, a preparation method thereof, and a pharmaceutical composition for the treatment of cancer comprising the same, and more particularly, to a novel compound prepared by linking chlorin e6 to folic acid, which effectively produces singlet oxygen in various media and has much better tumor selectivity than the known porphyrin-based photosensitizers, thereby being used effectively in photodynamic therapy for malignant tumors, a preparation method thereof, and a pharmaceutical composition for photodynamic treatment of solid tumors comprising the compound.

摘要翻译： 本发明涉及一种新的二氢卟吩e6-叶酸结合物，其制备方法和用于治疗癌症的药物组合物，特别涉及通过将二氢卟酚e6连接到叶酸而制备的新型化合物，其中 有效地在各种培养基中产生单线态氧，并且具有比已知的基于卟啉的光敏剂更好的肿瘤选择性，从而有效地用于恶性肿瘤的光动力学治疗，其制备方法和用于光动力治疗实体瘤的药物组合物，其包含化合物 。

公开(公告)号：US20120035180A1

公开(公告)日：2012-02-09

申请号：US12594180

申请日：2009-04-29

申请人： Kye Shin Park ,  Eun Hee Lee ,  Hyo Jun Kim

发明人： Kye Shin Park ,  Eun Hee Lee ,  Hyo Jun Kim

IPC分类号： A61K31/519 ,  A61P35/00

CPC分类号： A61K31/395 ,  A61K31/519 ,  A61K31/722 ,  A61K41/0071 ,  A61K47/551 ,  A61K2300/00

摘要： The present invention relates to a pharmaceutical composition for the treatment of cancer comprising a chlorin e6-folic acid conjugate compound and chitosan, and more particularly, to a pharmaceutical composition for photodynamic therapy of solid tumors comprising the novel chlorin e6-folic acid conjugate compound or a pharmaceutically acceptable salt thereof and chitosan, in which the novel compound is prepared by linking chlorin e6 to folic acid, and effectively produces singlet oxygen in various media and has much better tumor selectivity than the known porphyrin-based photosensitizers, thereby being used effectively in photodynamic treatment for malignant tumors.

摘要翻译： 本发明涉及用于治疗癌症的药物组合物，其包含二氢卟吩e6-叶酸结合化合物和壳聚糖，更具体地，涉及一种用于实体瘤的光动力疗法的药物组合物，其包含新的二氢卟吩e6-叶酸结合物或 其药学上可接受的盐和壳聚糖，其中通过将二氢卟酚e6连接到叶酸来制备新化合物，并且在各种培养基中有效产生单线态氧并且具有比已知的基于卟啉的光敏剂更好的肿瘤选择性，从而有效地用于 恶性肿瘤的光动力治疗。