公开(公告)号：US11858996B2

公开(公告)日：2024-01-02

申请号：US16323980

申请日：2017-08-09

申请人： Kymab Limited

发明人： Richard Charles Alfred Sainson ,  Stephen John Arkinstall ,  Jamie Iain Campbell ,  Mohammed Hanif Ali ,  E-Chiang Lee ,  Matthew John McCourt ,  Volker Germaschewski ,  Ian Kirby ,  Miha Kosmac ,  Nahida Parveen ,  Robert Rowlands ,  Gwenoline Borhis

IPC分类号： C07K16/02 ,  A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  A61K47/68 ,  A61K31/282 ,  C07K14/55 ,  C07K16/46 ,  G01N33/50 ,  A61K39/00

CPC分类号： C07K16/2818 ,  A61K31/282 ,  A61K39/395 ,  A61K47/6849 ,  A61P35/00 ,  C07K14/55 ,  C07K16/2827 ,  C07K16/468 ,  G01N33/5026 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/40 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92

摘要： Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.