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    Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
    3.
    发明授权
    Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics 有权

    公开(公告)号：US11051497B2

    公开(公告)日：2021-07-06

    申请号：US14220074

    申请日：2014-03-19

    申请人： Kymab Limited

    发明人： Glenn Friedrich ,  E-Chiang Lee ,  Jasper Clube ,  Nicholas England

    IPC分类号： A01K67/027 ,  C07K16/18 ,  C07K16/46 ,  C12N15/85 ,  C07K16/08 ,  C07K16/12 ,  C07K16/10

    摘要： The invention provides improved non-human vertebrates and non-vertebrate cells capable of expressing antibodies comprising human variable region sequences. The present invention is directed to the provision of long HCDR3s from non-human vertebrates and cells. The present invention is also directed to the provision of novel V, D and J pairings in immunoglobulin heavy and light chain loci. Novel, biased antibody diversities and potentially expanded diversities are provided. The invention also provides for novel and potentially expanded diversity or diversity that is biased towards variable gene usage common to antibodies useful for treating and/or preventing certain diseases or conditions, such as infectious diseases. The invention also provides methods of generating antibodies using such vertebrates, as well as the antibodies per se, therapeutic compositions thereof and uses.

    TRANSGENIC NON-HUMAN VERTEBRATE FOR THE IN VIVO PRODUCTION OF DUAL SPECIFICITY IMMUNOGLOBULINS OR HYPERMUTATED HEAVY CHAIN ONLY IMMUNOGLOBULINS
    4.
    发明申请
    TRANSGENIC NON-HUMAN VERTEBRATE FOR THE IN VIVO PRODUCTION OF DUAL SPECIFICITY IMMUNOGLOBULINS OR HYPERMUTATED HEAVY CHAIN ONLY IMMUNOGLOBULINS 审中-公开

    公开(公告)号：US20200267952A1

    公开(公告)日：2020-08-27

    申请号：US16869416

    申请日：2020-05-07

    申请人： Kymab Limited

    发明人： Volker Germaschewski ,  E-Chiang Lee ,  Hanif Ali ,  Jasper Clube

    IPC分类号： A01K67/027 ,  C12N15/85 ,  C07K16/00

    摘要： The invention relates, in one aspect, generally to novel concept of guided selection of antibody variable domains, combination and expression entirely in vivo. An application is to produce multivalent polypeptides. The present invention relates to multivalent (eg, multispecific) antibodies, antibody chains and polypeptides, as well as heavy chain-only antibodies (H2 antibodies) that are devoid of light chains. The invention further relates to the selection, maturation and production of these in vivo in non-human vertebrates and non-human vertebrate cells. To this end the invention also relates to such non-human vertebrates and cells. The invention also relates to the provision of means to produce and select heavy chain-only antibodies and heavy chains comprising variable domains that have undergone affinity maturation.

    SELECTIVE NAV PROTEIN BINDERS
    8.
    发明申请
    SELECTIVE NAV PROTEIN BINDERS 审中-公开

    公开(公告)号：US20170306013A1

    公开(公告)日：2017-10-26

    申请号：US15520204

    申请日：2015-10-20

    申请人： Kymab Limited

    发明人： Nigel Clark ,  E-Chiang Lee

    IPC分类号： C07K16/28 ,  A61K39/00

    CPC分类号： C07K16/28 ,  A61K2039/505

    摘要： The invention provides antibodies and fragments thereof which bind to human Nav1.7, as well as nucleic acids, vectors, host cells and hybridomas for making the same. Further provided are pharmaceutical compositions for use in treating, preventing and/or reducing the risk of a NAV1.7-mediated conditions or diseases, such as pain, inflammation, and metabolic/chronic diseases. The invention additionally provides methods of generating an antibody against a NAV protein of interest.