公开(公告)号：US10604576B2

公开(公告)日：2020-03-31

申请号：US15480525

申请日：2017-04-06

申请人： Kymab Limited

发明人： Jamie Campbell ,  Nikole Sandy Nee Waddell ,  Stephen D. Gillies ,  Volker Germaschewski ,  Cassandra van Krinks ,  Ian Kirby ,  Miha Kosmac ,  Steve Arkinstall ,  Thomas Gallagher

IPC分类号： C07K16/28 ,  A61K39/395 ,  C07K14/55 ,  C07K16/46 ,  C07K19/00 ,  A61K39/00

摘要： The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

公开(公告)号：US20170362321A1

公开(公告)日：2017-12-21

申请号：US15480525

申请日：2017-04-06

申请人： Kymab Limited

发明人： Jamie Campbell ,  Nikole Sandy Nee Waddell ,  Stephen D. Gillies ,  Volker Germaschewski ,  Cassandra van Krinks ,  Ian Kirby ,  Miha Kosmac ,  Steve Arkinstall ,  Thomas Gallagher

IPC分类号： C07K16/28 ,  C07K14/55 ,  C07K16/46

CPC分类号： C07K16/2827 ,  A61K2039/505 ,  C07K14/55 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/468 ,  C07K19/00 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/524 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/30 ,  C07K2319/74

摘要： The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.