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公开(公告)号：US10604576B2
公开(公告)日：2020-03-31
申请号：US15480525
申请日：2017-04-06
申请人： Kymab Limited
发明人： Jamie Campbell , Nikole Sandy Nee Waddell , Stephen D. Gillies , Volker Germaschewski , Cassandra van Krinks , Ian Kirby , Miha Kosmac , Steve Arkinstall , Thomas Gallagher
摘要： The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.
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公开(公告)号：US20170362321A1
公开(公告)日：2017-12-21
申请号：US15480525
申请日：2017-04-06
申请人： Kymab Limited
发明人： Jamie Campbell , Nikole Sandy Nee Waddell , Stephen D. Gillies , Volker Germaschewski , Cassandra van Krinks , Ian Kirby , Miha Kosmac , Steve Arkinstall , Thomas Gallagher
CPC分类号： C07K16/2827 , A61K2039/505 , C07K14/55 , C07K16/28 , C07K16/2803 , C07K16/468 , C07K19/00 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/74
摘要： The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.
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公开(公告)号：US09617338B1
公开(公告)日：2017-04-11
申请号：US15354971
申请日：2016-11-17
申请人： Kymab Limited
发明人： Jamie Campbell , Nikole Sandy , Stephen D. Gillies , Volker Germaschewski , Cassandra van Krinks , Ian Kirby , Miha Kosmac , Steve Arkinstall , Thomas Gallagher
CPC分类号： C07K16/2827 , A61K2039/505 , C07K14/55 , C07K16/28 , C07K16/2803 , C07K16/468 , C07K19/00 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/74
摘要： The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.
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公开(公告)号：US09957323B2
公开(公告)日：2018-05-01
申请号：US15698600
申请日：2017-09-07
申请人： KYMAB LIMITED
发明人： Richard Charles Alfred Sainson , Stephen John Arkinstall , Jamie Iain Campbell , Mohammed Hanif Ali , E-Chiang Lee , Matthew John McCourt , Nikole Sandy , Cassandra Van Krinks , Volker Germaschewski , Ian Kirby , Miha Kosmac , Thomas Gallagher , Cecilia Deantonio , Stephen D. Gillies
IPC分类号： C07K16/28 , A61K39/395 , C07K16/46 , C07K14/55
CPC分类号： C07K16/2827 , A61K2039/505 , C07K14/55 , C07K16/28 , C07K16/2803 , C07K16/468 , C07K19/00 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/74
摘要： Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.
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公开(公告)号：US09567399B1
公开(公告)日：2017-02-14
申请号：US15211504
申请日：2016-07-15
申请人： Kymab Limited
发明人： Jamie Campbell , Nikole Sandy , Stephen D. Gillies , Volker Germaschewski , Cassandra van Krinks , Ian Kirby , Miha Kosmac , Steve Arkinstall , Thomas Gallagher
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2827 , A61K2039/505 , C07K14/55 , C07K16/28 , C07K16/2803 , C07K16/468 , C07K19/00 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/74
摘要： The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.
摘要翻译： 本发明涉及抗PD-L1抗体，含有对PD-L1具有特异性的一个结构域的双特异性抗体，以及包含与细胞因子如IL-2融合的抗-PD-L1抗体的免疫细胞因子。 本发明还提供了包含抗体，双特异性抗体和免疫细胞因子的治疗，用途和药物组合物的方法。
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