公开(公告)号：US20050069967A1

公开(公告)日：2005-03-31

申请号：US10867912

申请日：2004-06-15

申请人： Kyoichi Sumida ,  Minoru Fujita ,  Hiromichi Adachi

发明人： Kyoichi Sumida ,  Minoru Fujita ,  Hiromichi Adachi

IPC分类号： G01N33/543 ,  G01N33/577 ,  G01N33/53

CPC分类号： G01N33/54313

摘要： The present invention relates to (1) A reagent for an immunoassay of a target substance existing in a free form and a bound form in a specimen, comprising a latex 1 which is immobilized with a monoclonal antibody 1 for the target substance, and a latex 2 which has a different mean particle size from the latex 1 and is immobilized with a monoclonal antibody 2 having a different recognition site for the target substance from the antibody 1, (2) An immunoassay method comprising reacting the target substance with the reagent of (1) and determining an amount of the substance based on the result of an agglutination reaction among the target substance, the latex1 and the latex2, and (3) A reagent kit comprising a reagent of (1) and a reagent containing an agglutination accelerator for an antigen-antibody reaction.

摘要翻译： 本发明涉及（1）一种试样中游离形式和结合形式存在的目标物质的免疫测定试剂，其特征在于，包含用目标物质单克隆抗体1固定的胶乳1和胶乳 2，其具有与胶乳1不同的平均粒度，并且用来自抗体1的靶物质具有不同识别位点的单克隆抗体2固定化。（2）一种免疫测定方法，包括使目标物质与（ 1），并且基于目标物质，胶乳1和胶乳2之间的凝集反应结果确定物质的量，和（3）包含试剂（1）的试剂盒和含有凝集促进剂的试剂 抗原 - 抗体反应。

公开(公告)号：US07279339B2

公开(公告)日：2007-10-09

申请号：US10867912

申请日：2004-06-15

申请人： Kyoichi Sumida ,  Minoru Fujita ,  Hiromichi Adachi

发明人： Kyoichi Sumida ,  Minoru Fujita ,  Hiromichi Adachi

IPC分类号： G01N33/543

CPC分类号： G01N33/54313

摘要： The present invention relates to (1) A reagent for an immunoassay of a target substance existing in a free form and a bound form in a specimen, comprising a latex 1 which is immobilized with a monoclonal antibody 1 for the target substance, and a latex 2 which has a different mean particle size from the latex 1 and is immobilized with a monoclonal antibody 2 having a different recognition site for the target substance from the antibody 1, (2) An immunoassay method comprising reacting the target substance with the reagent of (1) and determining an amount of the substance based on the result of an agglutination reaction among the target substance, the latex1 and the latex2, and (3) A reagent kit comprising a reagent of (1) and a reagent containing an agglutination accelerator for an antigen-antibody reaction.

摘要翻译： 本发明涉及（1）一种试样中游离形式和结合形式存在的目标物质的免疫测定试剂，其特征在于，包含用目标物质单克隆抗体1固定的胶乳1和胶乳 2，其具有与胶乳1不同的平均粒度，并且用来自抗体1的靶物质具有不同识别位点的单克隆抗体2固定化。（2）一种免疫测定方法，包括使目标物质与（ 1），并且基于目标物质，胶乳1和胶乳2之间的凝集反应结果确定物质的量，和（3）包含试剂（1）的试剂盒和含有凝集促进剂的试剂 抗原 - 抗体反应。

公开(公告)号：US20060172351A1

公开(公告)日：2006-08-03

申请号：US11394463

申请日：2006-03-30

申请人： Kyoichi Sumida ,  Minoru Fujita ,  Hiromichi Adachi

发明人： Kyoichi Sumida ,  Minoru Fujita ,  Hiromichi Adachi

IPC分类号： G01N33/574

CPC分类号： G01N33/54313

摘要： The present invention relates to (1) A reagent for an immunoassay of a target substance existing in a free form and a bound form in a specimen, comprising a latex 1 which is immobilized with a monoclonal antibody 1 for the target substance, and a latex 2 which has a different mean particle size from the latex 1 and is immobilized with a monoclonal antibody 2 having a different recognition site for the target substance from the antibody 1, (2) An immunoassay method comprising reacting the target substance with the reagent of (1) and determining an amount of the substance based on the result of an agglutination reaction among the target substance, the latex1 and the latex2, and (3) A reagent kit comprising a reagent of (1) and a reagent containing an agglutination accelerator for an antigen-antibody reaction.

摘要翻译： 本发明涉及（1）一种试样中游离形式和结合形式存在的目标物质的免疫测定试剂，其特征在于，包含用目标物质单克隆抗体1固定的胶乳1和胶乳 2，其具有与胶乳1不同的平均粒度，并且用来自抗体1的靶物质具有不同识别位点的单克隆抗体2固定化。（2）一种免疫测定方法，包括使目标物质与（ 1），基于目标物质，胶乳1和胶乳2之间的凝集反应结果确定物质的量，（3）包含试剂（1）的试剂盒和含有凝集物的试剂 促进剂用于抗原 - 抗体反应。

公开(公告)号：US06558481B1

公开(公告)日：2003-05-06

申请号：US09831790

申请日：2001-05-14

申请人： Hiromichi Adachi ,  Hiromitsu Ino ,  Hirosi Miwa

发明人： Hiromichi Adachi ,  Hiromitsu Ino ,  Hirosi Miwa

IPC分类号： H01F104

CPC分类号： H01F1/408 ,  H01F1/0018

摘要： An appropriate ferromagnetic substance, whose magnetization arises mainly from samarium, is selected, and the composition of this ferromagnetic samarium substance is, according to necessity, modified by an atomic substitution or addition; whereby the two parts of the magnetization originating from the orbital magnetic moment and the spin one compensate with each other and the resultant total magnetization becomes close to zero. An external magnetic field is applied to this ferromagnetic samarium substance at a temperature, where it has a finite magnetization, so as to align the electron spin polarization therein over a macroscopic range, and, subsequently, the temperature is set to be the magnetization-compensation temperature and the applied field is reduced to be nearly zero; whereby this ferromagnetic samarium substance can have a specific property. Since this property is useful to generate a spin-polarized charged-particle beam, to measure the spin polarization, and to polarize or analyze the spin for a charged-particle flow (an electric current), this ferromagnetic samarium substance can be a material for a spin-resolving device.

摘要翻译： 选择其磁化主要来自钐的合适的铁磁物质，根据需要，该铁磁性钐物质的组成可以通过原子取代或添加进行改性; 由此源自轨道磁矩和自旋的磁化的两个部分彼此补偿，并且所得的总磁化强度变得接近零。 在这种铁磁性钐物质的温度下，在其具有有限磁化强度的情况下将外部磁场施加到外部磁场，以便在宏观范围内对准其中的电子自旋极化，随后将温度设定为磁化补偿 温度和施加场减少到几乎为零; 由此该铁磁性钐物质可以具有特定的性质。 由于该性质可用于产生自旋极化带电粒子束，测量自旋极化，并且极化或分析带电粒子流（电流）的自旋，该铁磁性钐物质可以是用于 旋转分离装置。