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    MOLECULAR PROBE FOR IMAGING OF PANCREATIC ISLET AND THE PRECURSOR, AND USE OF THE SAME
    1.
    发明申请
    MOLECULAR PROBE FOR IMAGING OF PANCREATIC ISLET AND THE PRECURSOR, AND USE OF THE SAME 审中-公开
    用于成像胰腺和前列腺的分子探针及其用途

    公开(公告)号：US20150231284A1

    公开(公告)日：2015-08-20

    申请号：US14673767

    申请日：2015-03-30

    申请人： Kyoto University ,  Arkray, Inc.

    发明人： Nobuya Inagaki ,  Hideo Saji ,  Kentaro Toyoda ,  Hiroyuki Kimura ,  Yu Ogawa ,  Konomu Hirao ,  Kenji Nagakawa ,  Hirokazu Matsuda

    IPC分类号： A61K51/08 ,  C07K14/435

    CPC分类号： A61K51/08 ,  C07K14/435 ,  C07K14/57563 ,  Y02P20/55

    摘要： A precursor of molecular probe for imaging of pancreatic islets is provided. A polypeptide represented by any one of the following formulae (1) to (4), or a polypeptide having a homology with the foregoing polypeptide. *-DESK* QMEEEAVRLFIEVVLK* NGGPSSGAPPPSK-NH2 (1) *-LSK* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH2 (2) *-SK* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH2 (3) *-K* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH2 (4), wherein *- indicates that an α-amino group at an N-terminus is protected by a protecting group or modified with a modifying group having no electric charge; K* indicates that an amino group of a side chain of a lysine is protected by a protecting group; and —NH2 indicates that a carboxyl group at a C-terminus is amidated.

    摘要翻译： 提供了用于胰岛成像的分子探针的前体。 由下式（1）至（4）中任一项表示的多肽或与前述多肽具有同源性的多肽。 * -DESK * QMEEEAVRLFIEVVLK * NGGPSSGAPPPSK-NH2（1）* -LSK * QMEEEAVRLFIEWLK * NGGPSSGAPPPSK-NH2（2）* -SK * QMEEEAVRLFIEWLK * NGGPSSGAPPPSK-NH2（3）* -K * QMEEEAVRLFIEWLK * NGGPSSGAPPPSK-NH2（4）其中 *表示N-末端的α-氨基被保护基保护或用不带电的修饰基团修饰; K *表示赖氨酸的侧链的氨基被保护基保护; 并且-NH 2表示C末端的羧基被酰胺化。

    Concentration measuring method, concentration test instrument, and concentration measuring apparatus
    2.
    再颁专利
    Concentration measuring method, concentration test instrument, and concentration measuring apparatus 有权
    浓度测定法，浓度检测仪，浓度测定仪

    公开(公告)号：USRE45764E1

    公开(公告)日：2015-10-20

    申请号：US14012158

    申请日：2013-08-28

    申请人： ARKRAY, Inc.

    发明人： Kenji Nagakawa ,  Hideaki Yamaoka

    IPC分类号： G01N27/416 ,  C12Q1/00 ,  G01N27/327

    CPC分类号： G01N27/3271 ,  C12Q1/001

    摘要： The present invention relates to technology for constructing a reaction system including a test target, an oxidation-reduction enzyme, and an electron mediator, and measuring the concentration of the test target by an electrochemical process. A Ru compound is used as the electron mediator. The present invention provides a concentration test instrument including a substrate, first and second electrodes formed on the substrate, and a reagent layer formed as a solid. The reagent layer contains an oxidation-reduction enzyme and a Ru compound, and is constituted so as to dissolve and construct a liquid phase reaction system when a sample liquid is supplied.

    摘要翻译： 本发明涉及用于构建包括测试对象，氧化还原酶和电子介体的反应系统的技术，并且通过电化学过程测量测试目标的浓度。 使用Ru化合物作为电子介体。 本发明提供了一种浓度测试仪器，其包括基板，形成在基板上的第一和第二电极以及形成为固体的试剂层。 试剂层含有氧化还原酶和Ru化合物，构成为在供给样品液时溶解并构成液相反应体系。