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公开(公告)号：US20240159751A1
公开(公告)日：2024-05-16
申请号：US18514032
申请日：2023-11-20
发明人： Koichiro HATA , Shinji Uemoto , Hirofumi Hirao , Toyonari Kubota
IPC分类号： G01N33/573 , A61K38/48 , G01N33/576
CPC分类号： G01N33/573 , A61K38/4886 , G01N33/576 , G01N2333/96494 , G01N2800/08 , G01N2800/085
摘要： New use of ADAMTS13 in the clinical filed is provided. The use of ADAMTS13 as a biomarker for monitoring the onset of liver damage, hepatic ischemia/reperfusion injury or the liver function after liver transplantation: a method of testing liver damage, a method of testing hepatic ischemia/reperfusion injury, or a method of testing the liver function after liver transplantation, each of the methods comprising measuring or monitoring the ADAMTS13 activity in a sample from a mammal; an agent for treating diseases selected from the group consisting of liver damage, hepatic ischemia/reperfusion injury and hepatic dysfunction after liver transplantation, which comprises ADAMTS13 or a mutant of ADAMTS13 as an effective ingredient.
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公开(公告)号：US11567080B2
公开(公告)日：2023-01-31
申请号：US16066111
申请日：2017-01-06
发明人： Koichiro Hata , Shinji Uemoto , Hirofumi Hirao , Toyonari Kubota
IPC分类号： G01N33/573 , A61K38/48 , G01N33/576
摘要： New use of ADAMTS13 in the clinical filed is provided. The use of ADAMTS13 as a biomarker for monitoring the onset of liver damage, hepatic ischemia/reperfusion injury or the liver function after liver transplantation: a method of testing liver damage, a method of testing hepatic ischemia/reperfusion injury, or a method of testing the liver function after liver transplantation, each of the methods comprising measuring or monitoring the ADAMTS13 activity in a sample from a mammal; an agent for treating diseases selected from the group consisting of liver damage, hepatic ischemia/reperfusion injury and hepatic dysfunction after liver transplantation, which comprises ADAMTS13 or a mutant of ADAMTS13 as an effective ingredient.
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