公开(公告)号：US20180200242A1

公开(公告)日：2018-07-19

申请号：US15918685

申请日：2018-03-12

申请人： INTERMUNE, INC.

发明人： Williamson Z. Bradford ,  Javier Szwarcberg

IPC分类号： A61K31/4412 ,  G01N33/68 ,  A61K31/4418 ,  G01N33/576

CPC分类号： A61K31/4412 ,  A61K31/4418 ,  G01N33/576 ,  G01N33/6893 ,  G01N2800/52 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/475

摘要： Methods are provided for administering pirfenidone to a patient that has exhibited abnormal biomarkers of liver function in response to pirfenidone administration. The methods include administering to a patient pirfenidone at doses lower than the full target dosage for a time period, followed by administering to the patient pirfenidone at the full target dosage. The methods also include administering pirfenidone at the full target dose with no reduction and administering permanently reduced doses of pirfenidone.

公开(公告)号：US09791460B2

公开(公告)日：2017-10-17

申请号：US14105891

申请日：2013-12-13

申请人： Industrial Technology Research Institute

发明人： Tzu-Ling Tseng ,  Hung-Yi Li ,  Yen-Peng Li ,  Angelina Huai-Lo Lee ,  Yi-Chen Liu ,  Ping-Fu Cheng ,  Wei-Ya Lin ,  Hong-Zen Yeh

IPC分类号： G01N33/53 ,  G01N33/49 ,  G01N33/50 ,  G01N33/576 ,  G01N33/487 ,  G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/487 ,  G01N33/49 ,  G01N33/50 ,  G01N33/5067 ,  G01N33/53 ,  G01N33/576 ,  G01N2333/70539 ,  G01N2333/96494 ,  G01N2333/9723 ,  G01N2800/085

摘要： Identification of urokinase-type plasminogen, matrix metalloproteinase 9, and β-2-microglobulin as novel biomarkers associated with liver fibrosis and uses thereof in diagnosing liver fibrosis.

公开(公告)号：US20170022481A1

公开(公告)日：2017-01-26

申请号：US15213766

申请日：2016-07-19

申请人： GRIFOLS, S.A.

发明人： BRETT BUNO ,  TERRI JOURNIGAN ,  JOANN HOTTA ,  MICHAEL BURDICK

IPC分类号： C12N7/00 ,  C12N5/00 ,  C12Q1/70

CPC分类号： C12N7/00 ,  C12N5/0018 ,  C12N2501/05 ,  C12N2770/28151 ,  C12Q1/706 ,  C12Q1/707 ,  G01N33/576

摘要： Polybrene as an additive in cell culture medium is used in methods for the generation of high-titer hepatitis E virus stocks and assays for titration of hepatitis E virus. A cell culture medium containing polybrene is used for high-titer HEV generation, a method for determining the presence and/or the level of HEV in a sample, and an HEV titration assay using polybrene.

摘要翻译： 聚乙二醇作为细胞培养基中的添加剂用于产生高滴度戊型肝炎病毒库存和用于滴定戊型肝炎病毒的测定法。 使用含有聚凝胺的细胞培养基用于高滴度HEV产生，用于测定样品中HEV的存在和/或水平的方法以及使用聚凝胺的HEV滴定测定。

公开(公告)号：US20170010264A1

公开(公告)日：2017-01-12

申请号：US15270848

申请日：2016-09-20

申请人： Gale W. NEWMAN ,  Sam ANYANWU

发明人： Gale W. NEWMAN ,  Sam ANYANWU

IPC分类号： G01N33/569 ,  C12Q1/70

CPC分类号： G01N33/56988 ,  C12Q1/70 ,  C12Q1/703 ,  C12Q1/706 ,  C12Q1/707 ,  G01N1/40 ,  G01N33/493 ,  G01N33/56983 ,  G01N33/576 ,  G01N33/6893 ,  G01N2333/02 ,  G01N2333/10 ,  G01N2333/161 ,  G01N2333/162 ,  G01N2333/163 ,  G01N2333/186 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56 ,  Y02A50/54

摘要： A method for diagnosing hepatitis virus infection or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers present on exosomes in a bodily fluid sample from the subject is disclosed. Also disclosed are a method for monitoring the course of a hepatitis virus infection or a hepatitis disease condition in a subject and a method for monitoring effectiveness of treatment to a subject with an anti-hepatitis virus agent based on hepatitis virus-associated biomarkers present on exosomes in bodily fluid samples from the subject, as well as a kit for diagnosing hepatitis virus infection and/or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers on exosomes in bodily fluid samples from the subject.

摘要翻译： 公开了一种用于诊断受试者中基于肝炎病毒相关生物标志物的肝炎病毒感染或肝炎病症的方法，所述肝炎病毒相关生物标志物存在于来自受试者的体液样品中的外来体上。 还公开了一种用于监测受试者中肝炎病毒感染或肝炎疾病状况的过程的方法以及基于存在于外来体上的肝炎病毒相关生物标志物来监测具有抗肝炎病毒剂的受试者治疗有效性的方法 来自受试者的体液样本，以及用于诊断受试者中基于肝炎病毒相关生物标志物的肝炎病毒感染和/或肝炎疾病状况的试剂盒，其来自受试者的体液样品中的外来体。

公开(公告)号：US20160003819A1

公开(公告)日：2016-01-07

申请号：US14427972

申请日：2013-09-11

申请人： FORCE DIAGNOSTICS, INC

发明人： Michael P. CURRAN ,  David H. OSTROW ,  Brian MULCONREY ,  Tedd C. DETERMAN

IPC分类号： G01N33/558 ,  G01N33/72 ,  G01N33/68 ,  G01N33/569 ,  G01N33/576

CPC分类号： G01N33/558 ,  G01N33/56988 ,  G01N33/57434 ,  G01N33/576 ,  G01N33/6854 ,  G01N33/723 ,  G01N2333/4737 ,  G01N2333/58 ,  G01N2333/775 ,  G01N2800/08

摘要： The present invention relates to rapid test devices, kits and systems comprising the rapid test devices for assessing at least two analytes in a sample derived from a life or health insurance applicant, said at least two analytes being selected from the group consisting of a human immunodeficiency virus (HIV) antigen (e.g., a HIV polypeptide), a HIV polynucleotide, an anti-HIV antibody, a hepatitis C virus (HCV) antigen (e.g., a HCV polypeptide), a HCV polynucleotide, an anti-HCV antibody, a liver enzyme alanine transaminase (ALT), a liver enzyme aspartate transaminase (AST), nt-probnp (or NT-proBNP), probnp (or proBNP), cotinine, nicotine, cocaine, a metabolite of cocaine (e.g., benzoylecgonine), pro state-specific antigen (PSA), apolipoprotein A-1 (ApoA1), apolipoprotein B (ApoB), Hemoglobin Ale and high-sensitivity C-reactive protein (hsCRP). The present invention also relates to methods for using the rapid test devices, kits and systems as part of the assessment of the life or health insurance applications.

摘要翻译： 本发明涉及快速测试装置，试剂盒和系统，其包括用于评估来自生命或健康保险申请人的样品中的至少两种分析物的快速测试装置，所述至少两种分析物选自人免疫缺陷 病毒（HIV）抗原（例如，HIV多肽），HIV多核苷酸，抗HIV抗体，丙型肝炎病毒（HCV）抗原（例如，HCV多肽），HCV多核苷酸，抗HCV抗体， 肝酶丙氨酸转氨酶（ALT），肝酶天冬氨酸转氨酶（AST），nt-probnp（或NT-proBNP），probnp（或proBNP），可替宁，尼古丁，可卡因，可卡因的代谢物（例如苯并恶唑） 状态特异性抗原（PSA），载脂蛋白A-1（ApoA1），载脂蛋白B（ApoB），血红蛋白Ale和高敏C反应蛋白（hsCRP）。 本发明还涉及使用快速测试装置，套件和系统作为对生命或健康保险应用的评估的一部分的方法。

公开(公告)号：US20140106370A1

公开(公告)日：2014-04-17

申请号：US14105891

申请日：2013-12-13

申请人： Industrial Technology Research Institute

发明人： Tzu-Ling Tseng ,  Hong-Yi Li ,  Ye-Peng Li ,  Angelina Huai-Lo Lee ,  Yi-Chen Liu ,  Ping-Fu Cheng ,  Wei-Ya Lin ,  Hong-Zen Yeh

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/487 ,  G01N33/49 ,  G01N33/50 ,  G01N33/5067 ,  G01N33/53 ,  G01N33/576 ,  G01N2333/70539 ,  G01N2333/96494 ,  G01N2333/9723 ,  G01N2800/085

摘要： Identification of urokinase-type plasminogen, matrix metalloproteinase 9, and β-2-microglobulin as novel biomarkers associated with liver fibrosis and uses thereof in diagnosing liver fibrosis.

摘要翻译： 鉴定尿激酶型纤溶酶原，基质金属蛋白酶9和＆bgr.2-微球蛋白作为与肝纤维化相关的新型生物标志物及其在诊断肝纤维化中的用途。

公开(公告)号：US20130330749A1

公开(公告)日：2013-12-12

申请号：US13968292

申请日：2013-08-15

申请人： Masahiro SUGIMOTO ,  Tomoyoshi SOGA

发明人： Tomoyoshi SOGA ,  Masahiro SUGIMOTO ,  Makoto SUEMATSU ,  Masashi HONMA ,  Takehito YAMAMOTO ,  Hiroshi SUZUKI

IPC分类号： G01N33/487 ,  G01N33/497

CPC分类号： G01N33/487 ,  C07K5/0215 ,  G01N33/497 ,  G01N33/576 ,  G01N33/6812 ,  G01N33/6893 ,  G01N2800/08 ,  G01N2800/60

摘要： A normal person (i.e. a control) and liver diseases such as drug induced liver injury, an asymptomatic hepatitis B carrier, an asymptomatic hepatitis C carrier, chronic hepatitis B, chronic hepatitis C, liver cancer, a nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and simple steatosis (SS) are identified by measuring the concentrations of γ-Glu-X (X represents an amino acid or an amine) peptides or the levels of AST or ALT in blood and carrying out, for example, a multiple logistic regression based on the measured value.

摘要翻译： 正常人（即对照）和肝脏疾病如药物诱发的肝损伤，无症状乙型肝炎携带者，无症状丙型肝炎携带者，慢性乙型肝炎，慢性丙型肝炎，肝癌，非酒精性脂肪性肝病（NAFLD） 通过测量血液中的γ-Glu-X（X代表氨基酸或胺）肽的浓度或AST或ALT的水平，进行例如，通过测定非酒精性脂肪性肝炎（NASH）和简单脂肪变性（SS） ，基于测量值的多重逻辑回归。

公开(公告)号：US20130273525A1

公开(公告)日：2013-10-17

申请号：US13892521

申请日：2013-05-13

申请人： BIO-RAD INNOVATIONS

发明人： CHRISTINE CHARPENTIER ,  STEPHANE GADELLE ,  NADINE LAMBERT ,  AMPARO SANJUAN

IPC分类号： G01N33/569

CPC分类号： G01N33/56983 ,  G01N33/54333 ,  G01N33/569 ,  G01N33/56911 ,  G01N33/576 ,  G01N2333/02 ,  G01N2333/10 ,  Y02A50/54

摘要： The invention relates to a method for the in vitro diagnostic detection of an infection with a microorganism, comprising placing a biological sample, in a single assay receptacle, in the presence of particles, each carrying at least one specific detectable physical parameter, and belonging to at least two different groups, one of the groups carrying an anti-IgM capture antibody and the other group carrying a capture antigen derived from said microorganism.

摘要翻译： 本发明涉及用于体外诊断检测微生物感染的方法，包括将生物样品置于单个测定容器中，在存在颗粒的情况下，每个载体具有至少一个特定的可检测的物理参数，属于 至少两个不同的组，携带抗IgM捕获抗体的一个组，另一个携带来自所述微生物的捕获抗原的组。

公开(公告)号：US08489335B2

公开(公告)日：2013-07-16

申请号：US11596486

申请日：2005-05-13

申请人： Paul Cales

发明人： Paul Cales

IPC分类号： G01N33/48

CPC分类号： G01N33/576 ,  G01N33/6893 ,  G01N2800/085 ,  G01N2800/52 ,  G06F19/00 ,  G16H50/20 ,  Y02A90/24 ,  Y02A90/26

摘要： The invention relates to a method of diagnosing the presence and/or severity of a hepatic pathology and/or of monitoring the effectiveness of a curative treatment against a hepatic pathology in an individual, comprising the establishment of at least one non-invasive diagnostic score, in particular a diagnostic score for portal and septal fibrosis and/or an estimate score for the fibrosis area and/or an estimate score for the fractal dimension.

摘要翻译： 本发明涉及一种诊断肝病理学的存在和/或严重性和/或监测针对个体肝病理疗治疗的有效性的方法，包括建立至少一种非侵入性诊断评分， 特别是门静脉和间隔纤维化的诊断分数和/或纤维化区域的估计分数和/或分形维数的估计得分。

公开(公告)号：US20130085075A1

公开(公告)日：2013-04-04

申请号：US13487640

申请日：2012-06-04

申请人： George Sigal

发明人： George Sigal

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/576 ,  G01N2800/085 ,  Y02A50/54

摘要： The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or regimen. The invention also relates to assay kits used in connection with the diagnostic methods described herein.

摘要翻译： 本发明涉及诊断患者肝脏疾病的方法，以及监测肝脏疾病进展的方法和/或监测治疗剂或方案的治疗方案的方法。 本发明还涉及与本文所述诊断方法有关的测定试剂盒。