公开(公告)号：US20120195835A1

公开(公告)日：2012-08-02

申请号：US13359870

申请日：2012-01-27

申请人： Kyoungja WOO ,  Myung-Ik YOO

发明人： Kyoungja WOO ,  Myung-Ik YOO

IPC分类号： A61K49/10 ,  B82Y15/00

CPC分类号： B82Y15/00 ,  A61K49/186 ,  A61K49/1866 ,  G01N33/54353

摘要： A bio-imaging nanoparticle is composed of a core nanoparticle, a bonding layer having organic ligands, surfactants and polyoxyalkylene derivatives of fatty acid ester, and veiling the core nanoparticle, and functional molecules, wherein the organic ligands are bound to a surface of the core nanoparticle, the surfactants are bound to a portion of the surface of the core nanoparticle to which the organic ligands are not bound, the polyoxyalkylene derivatives of the fatty acid ester are introduced in an empty space between the organic ligands and the surfactants of the bonding layer, and the functional molecule is bound to a second terminal end opposite to a first terminal end of both terminal ends of the organic ligand, the first terminal end of the organic ligand being bound to a shell of the core nanoparticle.

摘要翻译： 生物成像纳米颗粒由核心纳米颗粒，具有有机配体的结合层，表面活性剂和脂肪酸酯的聚氧化烯衍生物，以及掩蔽核心纳米颗粒和功能分子组成，其中有机配体结合到核心的表面 纳米颗粒，表面活性剂结合到有机配体未结合的核心纳米颗粒表面的一部分，脂肪酸酯的聚氧化烯衍生物被引入有机配体和结合层的表面活性剂之间的空白空间 并且功能性分子结合到与有机配体的两个末端的第一末端相对的第二末端，有机配体的第一末端与核心纳米颗粒的壳结合。