公开(公告)号：US08507094B2

公开(公告)日：2013-08-13

申请号：US12979870

申请日：2010-12-28

申请人： Kyoungja Woo ,  Wooyoung Park

发明人： Kyoungja Woo ,  Wooyoung Park

IPC分类号： B32B5/16

CPC分类号： B01J13/02 ,  H01F1/0054 ,  H01F1/344 ,  Y10T428/2991

摘要： The present invention relates to a composite bead and a fabrication method thereof, and particularly, to a porous composite bead comprising superparamagnetic cluster and nanoparticles, such as light-emitting nanoparticles, magnetic nanoparticles, metallic nanoparticles, metal oxide nanoparticles and the like, and a fabrication method thereof.

摘要翻译： 复合珠及其制造方法技术领域本发明涉及复合珠及其制造方法，特别涉及包含超顺磁簇和纳米颗粒的多孔复合珠，例如发光纳米颗粒，磁性纳米颗粒，金属纳米颗粒，金属氧化物纳米颗粒等，以及 其制造方法。

公开(公告)号：US20130030206A1

公开(公告)日：2013-01-31

申请号：US13530401

申请日：2012-06-22

申请人： Kyoungja WOO ,  Seokheon LEE ,  Wooyoung PARK ,  Youngbeom YU

发明人： Kyoungja WOO ,  Seokheon LEE ,  Wooyoung PARK ,  Youngbeom YU

IPC分类号： C07F15/02 ,  B82Y30/00

CPC分类号： C01G49/08 ,  B82Y30/00 ,  B82Y40/00 ,  C01P2002/72 ,  C01P2004/52 ,  C01P2004/64 ,  C01P2006/42 ,  C30B7/00 ,  C30B29/16 ,  C30B29/22 ,  C30B29/60 ,  H01F1/0054 ,  Y10S977/788 ,  Y10S977/896

摘要： A superparamagnetic nanoparticle is comprised of superparamagnetic nanocrystals less than 20 nm in size, and molecules having containing 3 to 5 carboxyl groups, wherein the molecules bond to surfaces of the superparamagnetic nanocrystals. A method for producing superparamagnetic nanoparticles includes preparing an alkaline solution with pH 10 to 14, producing a mixture in which molecules containing 3 to 5 carboxyl groups, a divalent transition metal and ferric precursors are dissolved, and adding the mixture into the alkaline solution.

摘要翻译： 超顺磁性纳米粒子由尺寸小于20nm的超顺磁性纳米晶体和含有3至5个羧基的分子组成，其中分子键合到超顺磁性纳米晶体的表面。 制备超顺磁性纳米颗粒的方法包括制备pH10至14的碱性溶液，产生其中溶解含有3至5个羧基的分子，二价过渡金属和铁前体的混合物，并将该混合物加入到碱性溶液中。

公开(公告)号：US06603033B2

公开(公告)日：2003-08-05

申请号：US10052130

申请日：2002-01-16

申请人： Kyoungja Woo

发明人： Kyoungja Woo

IPC分类号： C07F728

CPC分类号： C07F7/003

摘要： The invention comprises an organotitanium precursor formed from a &bgr;-ketoester and a titanium glycolate, and dimer precursors formed from a reaction of the above organotitanium precursor with alcohol, which are used as sources of titanium dioxide for metal-organic chemical vapor deposition (MOCVD).

摘要翻译： 本发明包括由β-酮酯和乙醇酸钛形成的有机钛前体和由上述有机钛前体与醇反应形成的二聚体前体，其用作金属有机化学气相沉积（MOCVD）二氧化钛的来源， 。

公开(公告)号：US08691500B2

公开(公告)日：2014-04-08

申请号：US13560285

申请日：2012-07-27

申请人： Sang Kyung Kim ,  Kyoungja Woo ,  Yu Ri Choi

发明人： Sang Kyung Kim ,  Kyoungja Woo ,  Yu Ri Choi

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12M1/34 ,  G01N21/64

CPC分类号： G01N21/6428 ,  G01N2021/6432

摘要： Disclosed are a method for detecting a biomolecule including: immobilizing a nucleic acid aptamer capable of specifically binding to a biomolecule to be detected on the surface of a bead on which fluorophores are arranged; hybridizing the nucleic acid aptamer with a guard nucleic acid (g-nucleic acid) labeled with a quencher to quench fluorescence; and reacting a sample including the biomolecule to be detected with the nucleic acid aptamer and detecting a fluorescence signal emitted as the biomolecule binds with the nucleic acid aptamer and the g-nucleic acid labeled with the quencher is separated, and a device for detecting a biomolecule for conducting the detection method. The present disclosure allows for effective, convenient and fast detection of the biomolecule to be detected, enables quantitative analysis, and enables detection of even a trace amount of sample.

摘要翻译： 本发明公开了一种检测生物分子的方法，包括：将能够特异性结合待检测的生物分子的核酸适配体固定在配置有荧光体的珠粒的表面上; 将核酸适体与用猝灭剂标记的保护核酸（g-核酸）杂交以淬灭荧光; 并且使包含待检测的生物分子的样品与核酸适配体反应并检测作为生物分子发射的荧光信号与核酸适配体结合，并用猝灭剂标记的g-核酸被分离，并且用于检测生物分子的装置 用于进行检测方法。 本公开允许有效，方便和快速地检测待检测的生物分子，使得能够进行定量分析，并且甚至能够检测痕量的样品。

公开(公告)号：US20120195835A1

公开(公告)日：2012-08-02

申请号：US13359870

申请日：2012-01-27

申请人： Kyoungja WOO ,  Myung-Ik YOO

发明人： Kyoungja WOO ,  Myung-Ik YOO

IPC分类号： A61K49/10 ,  B82Y15/00

CPC分类号： B82Y15/00 ,  A61K49/186 ,  A61K49/1866 ,  G01N33/54353

摘要： A bio-imaging nanoparticle is composed of a core nanoparticle, a bonding layer having organic ligands, surfactants and polyoxyalkylene derivatives of fatty acid ester, and veiling the core nanoparticle, and functional molecules, wherein the organic ligands are bound to a surface of the core nanoparticle, the surfactants are bound to a portion of the surface of the core nanoparticle to which the organic ligands are not bound, the polyoxyalkylene derivatives of the fatty acid ester are introduced in an empty space between the organic ligands and the surfactants of the bonding layer, and the functional molecule is bound to a second terminal end opposite to a first terminal end of both terminal ends of the organic ligand, the first terminal end of the organic ligand being bound to a shell of the core nanoparticle.

摘要翻译： 生物成像纳米颗粒由核心纳米颗粒，具有有机配体的结合层，表面活性剂和脂肪酸酯的聚氧化烯衍生物，以及掩蔽核心纳米颗粒和功能分子组成，其中有机配体结合到核心的表面 纳米颗粒，表面活性剂结合到有机配体未结合的核心纳米颗粒表面的一部分，脂肪酸酯的聚氧化烯衍生物被引入有机配体和结合层的表面活性剂之间的空白空间 并且功能性分子结合到与有机配体的两个末端的第一末端相对的第二末端，有机配体的第一末端与核心纳米颗粒的壳结合。

公开(公告)号：US20110297871A1

公开(公告)日：2011-12-08

申请号：US12979870

申请日：2010-12-28

申请人： Kyoungja WOO ,  Wooyoung PARK

发明人： Kyoungja WOO ,  Wooyoung PARK

IPC分类号： H01F1/40 ,  H01F1/00 ,  B82Y30/00

CPC分类号： B01J13/02 ,  H01F1/0054 ,  H01F1/344 ,  Y10T428/2991

摘要： The present invention relates to a composite bead and a fabrication method thereof, and particularly, to a porous composite bead comprising superparamagnetic cluster and nanoparticles, such as light-emitting nanoparticles, s magnetic nanoparticles, metallic nanoparticles, metal oxide nanoparticles and the like, and a fabrication method thereof.

摘要翻译： 本发明涉及一种复合珠及其制造方法，特别涉及包含超顺磁簇和纳米颗粒的多孔复合珠，例如发光纳米颗粒，磁性纳米颗粒，金属纳米颗粒，金属氧化物纳米颗粒等，以及 其制造方法。

公开(公告)号：US08815272B2

公开(公告)日：2014-08-26

申请号：US13197946

申请日：2011-08-04

申请人： Kyoungja Woo ,  Hye Hun Park ,  Wooyoung Park

发明人： Kyoungja Woo ,  Hye Hun Park ,  Wooyoung Park

IPC分类号： A01N25/26 ,  B82Y30/00 ,  B82Y40/00 ,  B03C1/02 ,  B01D43/00 ,  B01J23/745 ,  B01J23/755 ,  B01J23/889 ,  B01J21/08 ,  B01J35/10 ,  B01J23/50 ,  B01J23/52

CPC分类号： B01J35/0033 ,  A01N25/26 ,  B01J23/40 ,  B01J23/50 ,  B01J23/52 ,  B01J23/74 ,  B01J31/0274 ,  B01J35/0013 ,  B01J37/0211 ,  B01J37/0221 ,  B01J37/024 ,  B01J37/0244 ,  B82Y30/00 ,  C07C213/02 ,  C07C215/76 ,  A01N59/16

摘要： An environment-friendly porous bead-satellite nanoparticles composite which has excellent recovery and repeated usage performance and can be used as a catalyst, an antiviral agent, or an antimicrobial, and a fabrication method thereof are provided. The porous bead-satellite nanoparticles composite includes a porous bead, a molecule having a first end coupled to the surface of the porous bead and including a functional group at a second end, and satellite nanoparticles coupled to the functional group, wherein the porous bead may have a core-shell structure including a cluster core of nanoparticles and a porous bead shell covering the cluster core.

摘要翻译： 提供了具有优异的回收率和重复使用性能并可用作催化剂，抗病毒剂或抗微生物剂的环境友好的多孔珠 - 卫星纳米复合材料及其制造方法。 多孔珠卫星纳米复合材料包括多孔珠，分子具有耦合到多孔珠的表面的第一末端并且在第二末端包含官能团，以及耦合到官能团的卫星纳米颗粒，其中多孔珠可以 具有核 - 壳结构，其包括纳米颗粒的簇核和覆盖簇核的多孔珠壳。

公开(公告)号：US20100224831A1

公开(公告)日：2010-09-09

申请号：US12618897

申请日：2009-11-16

申请人： Kyoungja WOO ,  Myungje CHO

发明人： Kyoungja WOO ,  Myungje CHO

IPC分类号： C09K11/54 ,  C09K11/77 ,  C09K11/08

CPC分类号： C09K11/565 ,  C09K11/02 ,  C09K11/025 ,  C09K11/642 ,  C09K11/7734 ,  C09K11/7738 ,  C09K11/7741 ,  C09K11/7787 ,  C09K11/7789 ,  C09K11/883 ,  C09K11/892

摘要： Disclosed are a nanoparticle-doped porous bead with a highly enhanced photoluminescence without wavelength shift and improved durability, and a fabrication method thereof, the nanoparticle-doped porous bead comprising porous beads, and nanoparticles radially bonded onto homocentric spheres of the porous beads by an electrostatic attractive force, the homocentric sphere located inside the porous bead near a surface thereof, wherein the nanoparticles are photoluminescent nanoparticles or mixed nanoparticles of photoluminescent nanoparticles and another nanoparticles, wherein the another nanoparticle is one or more than two mixed, selected from a group consisting of magnetic nanoparticle, metallic nanoparticle and metal oxide nanoparticle.

摘要翻译： 公开了具有高波长漂移和改善的耐久性的高度增强的光致发光的纳米颗粒掺杂多孔珠及其制造方法，包含多孔珠的纳米颗粒掺杂多孔珠粒和通过静电将多孔珠粒的均心球体径向结合的纳米颗粒 吸引力，位于其表面附近的多孔珠内的同心球，其中所述纳米颗粒是光致发光纳米颗粒或光致发光纳米颗粒和另一种纳米颗粒的混合纳米颗粒，其中所述另一种纳米颗粒是一种或两种以上混合的，选自 磁性纳米颗粒，金属纳米颗粒和金属氧化物纳米颗粒。

公开(公告)号：US07601391B2

公开(公告)日：2009-10-13

申请号：US11642772

申请日：2006-12-19

申请人： Kyoungja Woo ,  Dong Hyun Koo

发明人： Kyoungja Woo ,  Dong Hyun Koo

IPC分类号： B05D7/00 ,  B06B1/00 ,  B32B5/16

CPC分类号： B82Y30/00 ,  A61K49/0052 ,  A61K49/0054 ,  A61K49/0067 ,  B82Y5/00 ,  Y10S977/827 ,  Y10S977/83 ,  Y10T428/2998

摘要： There is provided an organic-inorganic composite material containing a single nanoparticle therein, which is prepared by individually dispersing hydrophilic inorganic nanoparticles having a uniform particle size and conjugating biodegradable polymers to the surface of the nanoparticle, and a method of preparing the same. More particularly, the preparation method of the present invention comprises the following steps: 1) preparing hydrophilic nanoparticles by conjugating organic substances having a thiol group and a hydrophilic amine group to the surface of a core or a core/shell inorganic nanoparticle protected with a surfactant through a metal-thiolate (M-S) bond between them; 2) adjusting the concentration of the hydrophilic nanoparticles prepared in step 1) to 2×10−6 M or less and treating them in a sonication bath to prepare individually dispersed nanoparticles in the form of a single particle; and 3) conjugating biopolymers to the nanoparticle individually dispersed in step 2) through the formation of an amide bond between them under treatment in a sonication bath. The organic-inorganic composite material of the present invention exhibits high efficient photoluminescence and photostability as well as excellent chemical stability, dispersibility in water, biocompatibility and targetibility. Thus, it can be effectively used as a raw material for bioimaging or film coating.

摘要翻译： 提供一种其中含有单一纳米颗粒的有机 - 无机复合材料，其通过将具有均匀粒度的亲水性无机纳米颗粒和将可生物降解的聚合物共轭分散在纳米颗粒的表面上而制备，及其制备方法。 更具体地说，本发明的制备方法包括以下步骤：1）通过将具有硫醇基和亲水性胺基的有机物质缀合到核表面或用表面活性剂保护的核/壳无机纳米颗粒的表面制备亲水性纳米颗粒 通过它们之间的金属硫醇盐（MS）键; 2）将步骤1）中制备的亲水性纳米颗粒的浓度调节至2×10 -6 M或更小，并在超声处理浴中处理以制备单个颗粒形式的单独分散的纳米颗粒; 和3）将生物聚合物与步骤2）中分散分散的纳米颗粒共轭，通过在超声处理浴中处理之间通过它们之间形成酰胺键。 本发明的有机 - 无机复合材料显示出高效的光致发光和光稳定性以及优异的化学稳定性，在水中的分散性，生物相容性和可目标性。 因此，其可以有效地用作生物成像或薄膜包衣的原料。

公开(公告)号：US20070248678A1

公开(公告)日：2007-10-25

申请号：US11235915

申请日：2005-09-26

申请人： Kyoungja Woo ,  Jong-Ku Park ,  Jae-Pyoung Ahn ,  Jangwon Hong

发明人： Kyoungja Woo ,  Jong-Ku Park ,  Jae-Pyoung Ahn ,  Jangwon Hong

IPC分类号： A61K9/14 ,  B32B15/02

CPC分类号： A61K49/1833 ,  A61K49/1836 ,  B82Y5/00 ,  Y10T428/12028

摘要： The present invention provides for a metal oxide nanoparticle that contains a metal core, a shell formed on the surface of the core and consisted of the same metal as the core, and an organic compound containing an element capable of covalently bonding with the nanoparticle and a hydrophilic functional group. According to the examples, uniform-sized hydrophilic metallic oxide-based nanoparticles are obtained when superparamagnetic iron oxide particles, which have a globular shape and are less than 20 nanometers in size, are first synthesized in an organic solution, and then are converted to hydrophilic particles after undergoing surface modification.

摘要翻译： 本发明提供了一种金属氧化物纳米颗粒，其包含金属芯，形成在芯的表面上并由与芯相同的金属组成的壳，以及含有能够与纳米颗粒共价结合的元素的有机化合物，以及 亲水官能团。 根据实施例，当在有机溶液中首先合成尺寸小于20纳米的超顺磁性氧化铁颗粒，然后转化为亲水性时，得到均匀尺寸的亲水性金属氧化物基纳米颗粒 经过表面改性后的颗粒。