公开(公告)号：US20130330361A1

公开(公告)日：2013-12-12

申请号：US14000587

申请日：2012-02-21

申请人： Kyu-Won Kim ,  Jong-Ho Cha

发明人： Kyu-Won Kim ,  Jong-Ho Cha

IPC分类号： A61K39/395 ,  C12N15/113

CPC分类号： A61K39/3955 ,  C12N15/113 ,  C12N2310/14

摘要： The invention includes a pharmaceutical composition comprising an expression or activity regulator of AKAP12 (A-kinase anchoring protein 12) as the active ingredient. The compositions of the invention are useful for treating central nervous system diseases. The invention further includes a method of treating central nervous system diseases using a pharmaceutical composition of the invention. The central nervous system diseases contemplated within the invention include post-traumatic stress syndrome, stroke, and spinal injury.

摘要翻译： 本发明包括含有作为活性成分的AKAP12（A激酶锚定蛋白12）的表达或活性调节剂的药物组合物。 本发明的组合物可用于治疗中枢神经系统疾病。 本发明还包括使用本发明的药物组合物治疗中枢神经系统疾病的方法。 本发明中考虑的中枢神经系统疾病包括创伤后应激综合征，中风和脊髓损伤。

公开(公告)号：US09089554B2

公开(公告)日：2015-07-28

申请号：US14000587

申请日：2012-02-21

申请人： Kyu-Won Kim ,  Jong-Ho Cha

发明人： Kyu-Won Kim ,  Jong-Ho Cha

IPC分类号： A01N37/18 ,  A61K38/00 ,  A61K39/395 ,  C12N15/113

CPC分类号： A61K39/3955 ,  C12N15/113 ,  C12N2310/14

摘要： The invention includes a pharmaceutical composition comprising an expression or activity regulator of AKAP12 (A-kinase anchoring protein 12) as the active ingredient. The compositions of the invention are useful for treating central nervous system diseases. The invention further includes a method of treating central nervous system diseases using a pharmaceutical composition of the invention. The central nervous system diseases contemplated within the invention include post-traumatic stress syndrome, stroke, and spinal injury.

摘要翻译： 本发明包括含有作为活性成分的AKAP12（A激酶锚定蛋白12）的表达或活性调节剂的药物组合物。 本发明的组合物可用于治疗中枢神经系统疾病。 本发明还包括使用本发明的药物组合物治疗中枢神经系统疾病的方法。 本发明中考虑的中枢神经系统疾病包括创伤后应激综合征，中风和脊髓损伤。

公开(公告)号：US20110123538A1

公开(公告)日：2011-05-26

申请号：US12999005

申请日：2008-12-24

申请人： Kyu-Won Kim ,  Hyo-Jong Lee

发明人： Kyu-Won Kim ,  Hyo-Jong Lee

IPC分类号： A61K39/395 ,  C07H21/02 ,  C07K16/28 ,  A61K38/02 ,  A61K31/713 ,  A61P25/28 ,  A61P17/00 ,  A61P17/06 ,  A61P9/10 ,  A61P29/00 ,  C12Q1/68 ,  G01N33/53

CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/14

摘要： The present invention relates to a composition comprising a Ninjurin 1 expression or activity inhibitor for the prevention and treatment of inflammatory disease. Ninjurin 1 protein is specifically expressed in macrophages around blood vessels, increases cell-cell adhesion and cell-matrix adhesion, increases expressions of Wnt7b (Wingless-type MMTV integration site family, member 7B) and Ang2 (angiopoietin-2), but reduces expression of Ang1 to induce apoptosis of vascular endothelial cells. In addition, Ninjurin 1 protein is up-regulated when inflammation is induced and induces iNOS expression as well as increased NO generation. Therefore, the Ninjurin 1 protein expression or activation inhibitor can be effectively used as an active ingredient of a composition for the prevention and treatment of inflammatory disease.

摘要翻译： 本发明涉及包含用于预防和治疗炎性疾病的Ninjurin1表达或活性抑制剂的组合物。 Ninjurin 1蛋白在血管周围的巨噬细胞中特异性表达，增加细胞粘附和细胞粘附，增加Wnt7b（Wingless型MMTV整合位点家族，成员7B）和Ang2（血管生成素-2）的表达， 的Ang1诱导血管内皮细胞凋亡。 此外，Ninjurin 1蛋白在诱导炎症时上调，诱导iNOS表达以及NO产生增加。 因此，Ninjurin 1蛋白质表达或激活抑制剂可以有效地用作预防和治疗炎性疾病的组合物的活性成分。

公开(公告)号：US08618072B2

公开(公告)日：2013-12-31

申请号：US13162226

申请日：2011-06-16

申请人： Kyu-Won Kim ,  Hyo-Jong Lee ,  Bum Ju Ahn

发明人： Kyu-Won Kim ,  Hyo-Jong Lee ,  Bum Ju Ahn

IPC分类号： A61K31/70 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68

CPC分类号： A61K39/3955 ,  A61K31/00 ,  A61K31/713 ,  A61K38/02 ,  A61K38/1709 ,  C07K14/705 ,  C07K16/28 ,  C07K2317/76 ,  C12N15/1138 ,  C12N2310/14 ,  G01N33/5023 ,  G01N2800/102 ,  G01N2800/205 ,  G01N2800/285 ,  G01N2800/323

摘要： The present invention relates to a composition comprising a Ninjurin1 expression or activity inhibitor for the prevention and treatment of inflammatory disease. Ninjurin1 protein is specifically expressed in macrophages around blood vessels, increases cell-cell adhesion and cell-matrix adhesion, increases expressions of Wnt7b (Wingless-type MMTV integration site family, member 7B) and Ang2 (angiopoietin-2), but reduces expression of Ang1 to induce apoptosis of vascular endothelial cells. In addition, Ninjurin1 protein is up-regulated when inflammation is induced and induces iNOS expression as well as increased NO generation. Therefore, the Ninjurin1 protein expression or activation inhibitor can be effectively used as an active ingredient of a composition for the prevention and treatment of inflammatory disease.

摘要翻译： 本发明涉及包含用于预防和治疗炎性疾病的Ninjurin1表达或活性抑制剂的组合物。 Ninjurin1蛋白在血管周围的巨噬细胞中特异性表达，增加细胞粘附和细胞粘附，增加Wnt7b（无翼型MMTV整合位点家族，成员7B）和Ang2（血管生成素-2）的表达， Ang1诱导血管内皮细胞凋亡。 此外，Ninjurin1蛋白在诱导炎症时上调，诱导iNOS表达以及NO产生增加。 因此，Ninjurin1蛋白质表达或激活抑制剂可以有效地用作预防和治疗炎性疾病的组合物的活性成分。

公开(公告)号：US08395701B2

公开(公告)日：2013-03-12

申请号：US12782299

申请日：2010-05-18

申请人： Jungwon Kim ,  Jaejin Lee ,  Kyu-Won Kim ,  Sung-Kwan Heo

发明人： Jungwon Kim ,  Jaejin Lee ,  Kyu-Won Kim ,  Sung-Kwan Heo

IPC分类号： H04N7/01 ,  H04N11/00

CPC分类号： H04N21/44008 ,  G09G2320/103 ,  G09G2340/0435 ,  H04N21/4126 ,  H04N21/41407 ,  H04N21/440281

摘要： Provided is an operating voltage scaling method for a portable terminal. The method includes, if reproduction of a moving image is requested, acquiring DYNamicity (DYN) of the reproduction-requested moving image, determining whether frame skipping is possible for the moving image according to the acquired DYN of the moving image, and if it is determined that frame skipping is possible for the moving image, supplying a low operating voltage to a controller of the mobile terminal to control the mobile terminal to operate with a low-speed clock, and reproducing the moving image while skipping a frame.

摘要翻译： 提供了一种用于便携式终端的操作电压缩放方法。 该方法包括：如果请求了运动图像的再现，则获取再现请求的运动图像的DYNamicity（DYN），根据获取的运动图像的DYN确定运动图像的跳帧是否可能，并且如果是 确定对于运动图像可能跳帧，向移动终端的控制器提供低工作电压以控制移动终端以低速时钟操作，并且在跳过帧时再现运动图像。

公开(公告)号：US20110162092A1

公开(公告)日：2011-06-30

申请号：US12997653

申请日：2009-06-12

申请人： Kyu-Won Kim ,  Hyouk-Bum Kwon

发明人： Kyu-Won Kim ,  Hyouk-Bum Kwon

IPC分类号： A61K38/45 ,  C12N9/12 ,  G01N33/00 ,  A61P7/04

CPC分类号： A61K38/1709

摘要： The present invention relates to a composition comprised of AKAP12 (A-Kinase anchoring protein 12) and to uses of AKAP12 mutant zebrafish as an animal model. More particularly, the following characteristics are noted in the present AKAP12 mRNA knockdown zebrafish: crooked or shortened tail, inability to move normally, non-uniform micro-vasculature in the brain, and change in heart shape with non-uniform and weak heartbeats. It also has various circulatory and genetic defects, such as hemorrhage from the ventricles of the heart, brain, and retina. All of these defects can be cured with AKAP12 injection. Therefore, AKAP12 can be used as an active component for a composition to prevent and heal circulatory and genetic defects that are caused by AKAP12 deficiency, and as a hemorrhage inhibitor. Further, the AKAP12 deficient mutant zebrafish can be useful as an animal model for verification of effectiveness of treatment for genetic defects in the circulatory system.

摘要翻译： 本发明涉及由AKAP12（A-激酶锚定蛋白12）组成的组合物和AKAP12突变斑马鱼作为动物模型的用途。 更具体地，在本发明的AKAP12mRNA敲低斑马鱼中注意到以下特征：弯曲或缩短的尾巴，不能正常移动，脑中不均匀的微血管系统，以及心脏形状与心脏不均匀和微弱的变化。 它还具有各种循环和遗传缺陷，例如来自心脏，脑和视网膜心室的出血。 所有这些缺陷都可以用AKAP12注射固化。 因此，AKAP12可用作组合物的活性成分，用于预防和治疗由AKAP12缺乏引起的循环和遗传缺陷，以及作为出血抑制剂。 此外，AKAP12缺陷突变体斑马鱼可用作验证循环系统遗传缺陷治疗有效性的动物模型。

公开(公告)号：US20100295990A1

公开(公告)日：2010-11-25

申请号：US12782299

申请日：2010-05-18

申请人： Jungwon KIM ,  Jaejin Lee ,  Kyu-Won Kim ,  Sung-Kwan Heo

发明人： Jungwon KIM ,  Jaejin Lee ,  Kyu-Won Kim ,  Sung-Kwan Heo

IPC分类号： H04N7/01

CPC分类号： H04N21/44008 ,  G09G2320/103 ,  G09G2340/0435 ,  H04N21/4126 ,  H04N21/41407 ,  H04N21/440281

摘要： Provided is an operating voltage scaling method for a portable terminal. The method includes, if reproduction of a moving image is requested, acquiring DYNamicity (DYN) of the reproduction-requested moving image, determining whether frame skipping is possible for the moving image according to the acquired DYN of the moving image, and if it is determined that frame skipping is possible for the moving image, supplying a low operating voltage to a controller of the mobile terminal to control the mobile terminal to operate with a low-speed clock, and reproducing the moving image while skipping a frame.

摘要翻译： 提供了一种用于便携式终端的操作电压缩放方法。 该方法包括：如果请求了运动图像的再现，则获取再现请求的运动图像的DYNamicity（DYN），根据获取的运动图像的DYN确定运动图像的跳帧是否可能，并且如果是 确定对于运动图像可能跳帧，向移动终端的控制器提供低工作电压以控制移动终端以低速时钟操作，并且在跳过帧时再现运动图像。

公开(公告)号：US08422996B2

公开(公告)日：2013-04-16

申请号：US12017753

申请日：2008-01-22

申请人： Kyu-Won Kim

发明人： Kyu-Won Kim

IPC分类号： H04M1/725

CPC分类号： H04M1/72547 ,  H04L12/1859 ,  H04L51/38 ,  H04W68/00

摘要： Provided is a system for providing a silent advertisement that includes a multimedia message server for generating a multimedia message containing at least one piece of silent advertisement data and transmitting the multimedia message to an arbitrary mobile terminal, and the mobile terminal for receiving the multimedia message, detecting and storing the silent advertisement data contained in the multimedia message without notifying a user, and if a current operational state of the mobile terminal corresponds to a pre-set silent advertisement output condition, outputting the silent advertisement data. Accordingly, provided is a method, apparatus, and system for silently transmitting advertisement data to a mobile terminal of a user even if the user does not request to receive advertisements in advance, which are used by a communication provider to modify advertisement data stored in advance in the mobile terminal of the user in response to a request of a sponsor.

摘要翻译： 提供了一种用于提供静音广告的系统，其包括：多媒体消息服务器，用于生成包含至少一个静音广告数据的多媒体消息，并将多媒体消息发送到任意的移动终端;以及移动终端，用于接收多媒体消息， 检测和存储多媒体消息中包含的静音广告数据，而不通知用户，并且如果移动终端的当前操作状态对应于预置的无声广告输出条件，则输出静音广告数据。 因此，提供了即使用户没有请求预先接收广告来通知用户的广告数据静默地发送的方法，装置和系统，由通信提供商使用来修改预先存储的广告数据 在用户的移动终端中响应于赞助者的请求。

公开(公告)号：US07960345B2

公开(公告)日：2011-06-14

申请号：US12376058

申请日：2007-05-02

申请人： Kyu-Won Kim

发明人： Kyu-Won Kim

IPC分类号： C07K14/515

CPC分类号： A61K38/1709 ,  C07K14/47

摘要： The present invention relates to an angiogenesis inhibitor comprising meteorin as an active ingredient that is highly expressed in astrocytes of the brain and retina in the late embryonic stage and after the birth of a mouse. It is in particular highly detected in astrocyte endfeet surrounding blood vessels and promotes the expression of thrombospondin-1/-2 (TSP-1/-2) via autocrine pathway and thus inhibits angiogenesis. The meteorin of the present invention can be effectively used for pharmaceutical compositions and health foods that prevent vascular diseases by inhibiting angiogenesis.

摘要翻译： 本发明涉及一种血管发生抑制剂，其包含在晚期胚胎期和小鼠出生后在大脑和视网膜的星形胶质细胞中高度表达的活性成分的流星。 在血管周围的星形胶质细胞末端特别高度检测到，通过自分泌途径促进血小板反应素-1 / -2（TSP-1 / -2）的表达，从而抑制血管生成。 本发明的气象可以有效地用于通过抑制血管发生来预防血管疾病的药物组合物和保健食品。

公开(公告)号：US20100048471A1

公开(公告)日：2010-02-25

申请号：US12376058

申请日：2007-05-02

申请人： Kyu-Won Kim

发明人： Kyu-Won Kim

IPC分类号： A61K38/17

CPC分类号： A61K38/1709 ,  C07K14/47

摘要： The present invention relates to an angiogenesis inhibitor comprising meteorin as an active ingredient that is highly expressed in astrocytes of the brain and retina in the late embryonic stage and after the birth of a mouse. It is in particular highly detected in astrocyte endfeet surrounding blood vessels and promotes the expression of thrombospondin-1/-2 (TSP-1/-2) via autocrine pathway and thus inhibits angiogenesis. The meteorin of the present invention can be effectively used for pharmaceutical compositions and health foods that prevent vascular diseases by inhibiting angiogenesis.

摘要翻译： 本发明涉及一种血管发生抑制剂，其包含在晚期胚胎期和小鼠出生后在大脑和视网膜的星形胶质细胞中高度表达的活性成分的流星。 在血管周围的星形胶质细胞末端特别高度检测到，通过自分泌途径促进血小板反应素-1 / -2（TSP-1 / -2）的表达，从而抑制血管生成。 本发明的气象可以有效地用于通过抑制血管发生来预防血管疾病的药物组合物和保健食品。