公开(公告)号：US20240082132A1

公开(公告)日：2024-03-14

申请号：US18267333

申请日：2021-12-10

Applicant: L'OREAL

Inventor： Romain TACHON ,  Amelie PREVOT-GUEGUINIAT ,  Makoto SAITO

IPC: A61K8/49 ,  A61Q5/08 ,  A61Q19/02

CPC classification number: A61K8/4926 ,  A61Q5/08 ,  A61Q19/02

Abstract: The present invention relates to a composition comprising: (a) at least one thiopyridinone compound; and (b) at least one fatty acid comprising 18 or more carbon atoms, wherein the amount of the (b) fatty acid(s) comprising 18 or more carbon atoms in the composition is 10% by weight or more, preferably 12% by weight or more, and more preferably 14% by weight or more, relative to the total weight of the composition. The present invention can provide a composition including (a) thiopyridinone compound(s) with increased stability of the (a) thiopyridinone compound(s) over time, in particular even when the composition is maintained for a relatively long period of time under elevated temperature, and with reduced yellowing just after adding the thiopyridinone compound to the composition.

公开(公告)号：US20240065960A1

公开(公告)日：2024-02-29

申请号：US18257731

申请日：2021-12-10

Applicant: L'OREAL

Inventor： Romain TACHON ,  Amelie PREVOT-GUEGUINIAT ,  Makoto SAITO

IPC: A61K8/49 ,  A61Q19/02

CPC classification number: A61K8/4926 ,  A61Q19/02 ,  A61K2800/52

Abstract: The present invention relates to a composition comprising: (a) at least one thiopyridinone compound; (b) at least one oil; and (c) water, wherein the composition comprises a continuous oil phase comprising the (b) at least one oil, a discontinuous aqueous phase comprising the (a) thiopyridinone compound and (c) water, dispersed in the oil phase, and the weight ratio of the aqueous phase to the oil phase is 1.0 to 10.0. The present invention can provide a composition including (a) thiopyridinone compound(s) with increased stability of the (a) thiopyridinone compound(s), even when the composition is maintained for a relatively long period of time under elevated temperature.