公开(公告)号：US20210340177A1

公开(公告)日：2021-11-04

申请号：US17051897

申请日：2020-04-30

Applicant: L'OREAL

Inventor： Rodrigo DE VECCHI ,  Lionel BRETON ,  Leonardo de Azevedo CALDERON ,  Fernando ZANCHI ,  Aleff Ferreira FRANCISCO

IPC: C07K5/10 ,  A61K8/64 ,  A61Q19/08 ,  A61P21/02

Abstract: Two synthetic tetrapeptides having a high binding affinity to human muscular nicotinic acetylcholine receptor (HmnAChR) are provided. A composition for inhibiting contraction of muscle cells is also provided. The composition comprises an effective amount of one of these two peptides. Also provided is a method for inhibiting contraction of muscle cells, which method comprises treating muscle cells with an effective amount of the composition. Further provided is a method for inducing proliferation of epidermal cells, which method comprises treating the epidermal cells with an effective amount of the composition. The epidermal cells may be human epidermal keratinocytes (HEKs).