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18 条记录 (耗时 0.026 秒)

    Topical treatment of ocular hypertension
    5.
    发明授权
    Topical treatment of ocular hypertension 失效
    局部治疗高眼压症

    公开(公告)号：US4477460A

    公开(公告)日：1984-10-16

    申请号：US435195

    申请日：1982-10-19

    申请人： L. David Waterbury ,  A. Peter Roszkowski

    发明人： L. David Waterbury ,  A. Peter Roszkowski

    IPC分类号： A61K31/425

    CPC分类号： A61K31/425 ,  Y10S514/912

    摘要： This invention concerns the novel use of certain known thiazoles, particularly acylaminothiazoles and thiazolecarboxamides, as intraocular pressure lowering agents. When administered topically to the eye with increased intraocular pressure the compounds are effective in decreasing intraocular pressure, in preventing development of acute or chronic ocular hypertension including glaucoma, in inhibiting the further deterioration of the eye due to intraocular hypertension, or in relieving the symptoms of already existing ophthalmic disease.

    摘要翻译： 本发明涉及某些已知的噻唑，特别是酰氨基噻唑和噻唑甲酰胺作为眼压降低剂的新用途。 当眼内压升高时，化合物有效降低眼内压，防止急性或慢性高眼压症（包括青光眼）的发展，抑制由于眼内高血压引起的眼睛的进一步恶化，或缓解眼睛的症状 已经存在眼科疾病。

    Arylalkyl amines useful for lowering intraocular pressure
    6.
    发明授权
    Arylalkyl amines useful for lowering intraocular pressure 失效
    用于降低眼内压的芳基烷基胺

    公开(公告)号：US4752621A

    公开(公告)日：1988-06-21

    申请号：US900199

    申请日：1986-08-25

    申请人： Robin D. Clark ,  L. David Waterbury

    发明人： Robin D. Clark ,  L. David Waterbury

    IPC分类号： C07C275/40 ,  A61K31/165 ,  A61K31/135 ,  A61K31/17

    CPC分类号： C07C275/40 ,  Y10S514/913

    摘要： Intraocular hypertensive diseases such as glaucoma are treated with compounds represented by formula I ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein R.sub.1 is alkyl of two to four carbon atoms;R.sub.2 is --(CH.sub.2).sub.n --C.sub.6 H.sub.4 --R.sub.5 ; wheren is an integer from 1 to 4; andR.sub.5 is --H, --OH, halo, lower alkyl, lower alkoxy, ureido, lower alkyl-ureido, lower alkyl-amido, or formamido;R.sub.3 is hydro or hydroxy; andR.sub.4 is hydro, lower alkyl, amino, or lower alkylamino.

    摘要翻译： 用式I（I）表示的化合物或其药学上可接受的酸加成盐处理眼内高血压疾病如青光眼，其中R1是2-4个碳原子的烷基; R2是 - （CH2）n-C6H4-R5; 其中n是1至4的整数; 并且R 5是-H，-OH，卤素，低级烷基，低级烷氧基，脲基，低级烷基 - 脲基，低级烷基 - 酰氨基或甲酰氨基; R3是氢或羟基; 并且R 4是氢，低级烷基，氨基或低级烷基氨基。

    Treatment and prevention of ocular hypertension
    7.
    发明授权
    Treatment and prevention of ocular hypertension 失效
    治疗和预防眼高压

    公开(公告)号：US4558066A

    公开(公告)日：1985-12-10

    申请号：US611245

    申请日：1984-05-17

    申请人： L. David Waterbury

    发明人： L. David Waterbury

    IPC分类号： C07D405/06 ,  A61K31/40

    CPC分类号： C07D405/06

    摘要： This invention relates to a method of treatment of ocular hypertension and to a topical ophthalmic pharmaceutical composition useful for management of ocular hypertension.When administered topically to an eye with increased intraocular pressure, .+-.2-[(3,4-methylenedioxy)phenethyl]-5-[(3-carboxamido-4-hydroxy)-.alpha.-hydroxybenzyl]pyrrolidines effectively decrease intraocular pressure, inhibit the deterioration of the eye due to intraocular hypertension or glaucoma and relieve the symptoms of already existing glaucoma or other ophthalmic disease.

    摘要翻译： 本发明涉及治疗高眼压症的方法和用于治疗高眼压症的局部眼用药物组合物。 当局部施用眼压增高的眼睛时，+/- 2 - [（3,4-亚甲二氧基）苯乙基] -5 - [（3-甲酰胺基-4-羟基）-α-羟基苄基]吡咯烷有效降低眼内压， 抑制由于眼内高血压或青光眼引起的眼睛的退化，并缓解已经存在的青光眼或其它眼科疾病的症状。

    11-substituted-16-phenoxy and 16-substituted phenoxy-prostatrienioc acid derivatives
    9.
    发明授权
    11-substituted-16-phenoxy and 16-substituted phenoxy-prostatrienioc acid derivatives 失效
    11-取代的-16-苯氧基和16-取代的苯氧基 - 前列腺素衍生物

    公开(公告)号：US4792617A

    公开(公告)日：1988-12-20

    申请号：US18766

    申请日：1987-02-27

    申请人： Gary F. Cooper ,  John H. Fried ,  L. David Waterbury

    发明人： Gary F. Cooper ,  John H. Fried ,  L. David Waterbury

    IPC分类号： C07C405/00 ,  C07C177/00

    CPC分类号： C07C405/00

    摘要： This invention covers a compound of the formula ##STR1## wherein R is hydrogen, lower alkyl or a pharmaceutically acceptable, non-toxic salt of a compound wherein R is hydrogen; X is hydrogen, halo, trifluoromethyl, lower alkyl or lower alkoxy, Y is lower alkyl or ##STR2## wherein Z is hydrogen, halo, methyl, methoxy or trifluoromethyl; and the wavy lines represent the .alpha. or .beta. configuration with the proviso that when one wavy line is .alpha. the other is .beta..

    摘要翻译： 本发明涵盖下式的化合物，其中R是氢，其中R是氢的化合物的低级烷基或药学上可接受的无毒盐; X是氢，卤素，三氟甲基，低级烷基或低级烷氧基，Y是低级烷基或者其中Z是氢，卤素，甲基，甲氧基或三氟甲基; 波浪线表示α或β配置，条件是当一条波浪线为α时，另一条波长为β。

    Use of pyrrolo-pyrrole in treating microvascular diseases associated with diabetes
    10.
    发明授权
    Use of pyrrolo-pyrrole in treating microvascular diseases associated with diabetes 失效
    吡咯并吡咯用于治疗与糖尿病有关的微血管疾病

    公开(公告)号：US4457941A

    公开(公告)日：1984-07-03

    申请号：US360753

    申请日：1982-03-22

    申请人： Howard J. Ringold ,  L. David Waterbury

    发明人： Howard J. Ringold ,  L. David Waterbury

    IPC分类号： A61K31/40

    CPC分类号： A61K31/40

    摘要： The present invention concerns a new use of certain pyrrolo-pyrrole compounds of chemical formulas (A), (B), (C), and (D): ##STR1## for the treatment of microvascular complications associated with diabetes such as, for example, diabetic retinopathy, diabetic nephropathy and diabetic neuropathy. Pyrrolo-pyrrole compounds prevent development, restrain further progress and relieve symptoms of already developed microvascular complications of diabetes.

    摘要翻译： 本发明涉及化学式（A），（B），（C）和（D）的某些吡咯并吡咯化合物的新用途：（A） ）（D）用于治疗与糖尿病有关的微血管并发症，例如糖尿病性视网膜病变，糖尿病肾病和糖尿病性神经病变。 吡咯并吡咯化合物预防发展，抑制进一步的进展，缓解已发展的糖尿病微血管并发症的症状。