公开(公告)号：US20140350110A1

公开(公告)日：2014-11-27

申请号：US14324448

申请日：2014-07-07

Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.

Inventor： Helmut Heinrich BUSCHMANN ,  Lluis SOLA CARANDELL ,  Jordi BENET BUCHHOLZ ,  Jordi Carles CERON BERTRAN ,  Carlos Ramon PLATA SALAMAN ,  Nicolas TESSON

IPC: A61K31/192 ,  A61K31/135

CPC classification number: A61K31/635 ,  A61K9/16 ,  A61K31/135 ,  A61K31/137 ,  A61K31/192 ,  A61K45/06 ,  C07B2200/13 ,  C07C59/64 ,  C07C217/74 ,  C07C2601/14 ,  C07D231/12 ,  A61K2300/00

Abstract: The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.

Abstract translation: 本发明涉及选自NSAIDs的曲马多和共晶体形成剂的共晶体，其制备方法及其作为药物的用途或药物制剂，特别是用于治疗疼痛。