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1.发明申请公开(公告)号：US20190177337A1
公开(公告)日：2019-06-13
申请号：US16275676
申请日：2019-02-14
发明人： Marina VIRGILI-BERNADO , Monica Alonso-Xalma , Carlos Alegret-Molina , Carmen Almansa-Rosales , Monica Garcia-Lopez
IPC分类号： C07D498/10
摘要： The present invention relates to compounds having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opioid receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
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公开(公告)号：US20190031615A1
公开(公告)日：2019-01-31
申请号：US16069529
申请日：2017-01-13
IPC分类号： C07D223/04 , C07D401/12
摘要： The present invention relates to 3-ethyl-3-phenylazepane derivatives having dual pharmacological activity towards both the sigma (σ) receptor and the μ-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
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3.发明申请公开(公告)号：US20180251430A1
公开(公告)日：2018-09-06
申请号：US15757177
申请日：2016-09-01
IPC分类号： C07D231/12
CPC分类号： C07D231/12 , C07B2200/13 , C07D403/12
摘要： The present invention relates to 1-(4-(2-((1-(3,4-difluorophenyl)-1 H-pyrazol-3-yl)methoxy)ethyl)piperazin-1-yl)ethanone salts, specifically to the hydrochloride and to the maleate, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of sigma receptor associated diseases.
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公开(公告)号：US20180230148A1
公开(公告)日：2018-08-16
申请号：US15571352
申请日：2016-05-04
IPC分类号： C07D471/10
CPC分类号： C07D471/10
摘要： The present invention relates to compounds having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opiod receptor and more particularly to spiro-isoquinoline-4,4′-piperidine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
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公开(公告)号：US20170202950A1
公开(公告)日：2017-07-20
申请号：US15463176
申请日：2017-03-20
申请人： LABORATORIOS DEL DR ESTEVE, S.A. , FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CA , INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS , UNIVERSITY OF WASHINGTON
IPC分类号： A61K39/21 , C12N7/00 , C07K14/005
CPC分类号： A61K39/21 , A61K38/00 , A61K39/12 , A61K2039/572 , C07K7/08 , C07K14/005 , C12N7/00 , C12N2740/16021 , C12N2740/16034 , C12N2740/16071 , C12N2740/16222 , C12N2740/16234 , G01N33/505 , G01N2333/161
摘要： The invention relates to peptides comprising part or all of a conserved element within a Center-of-Tree (COT) sequence derived from a family of polypeptides encoded by naturally occurring variants of HIV. The invention also relates to immunogenic compositions and vaccines comprising said peptides. The invention also relates to methods for the identification of HIV controller patients based on the detection of the T cells of the patient to mount a cytotoxic T cell response against said peptides and to methods for the identification of immunogenic peptides within a family of variant polypeptides.
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公开(公告)号：US20170088859A1
公开(公告)日：2017-03-30
申请号：US15310524
申请日：2015-05-13
CPC分类号： C12N15/86 , A61K38/47 , A61K48/00 , A61K48/005 , A61K48/0075 , C12N9/2474 , C12N2750/14143 , C12N2800/22 , C12N2830/008 , C12N2840/105 , C12Y302/0105
摘要： The present invention provides new adenoassociated virus vectors and pharmaceutical compositions containing the same for the treatment of lysosomal storage disorders and specially, for the treatment of mucopolysaccharidoses Type IIIB.
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![Substituted pyrazolo[1,5-A]pyridines, their preparation and use as medicaments](/abs-image/US/2016/11/08/US09487513B2/abs.jpg.150x150.jpg)
7.发明授权Substituted pyrazolo[1,5-A]pyridines, their preparation and use as medicaments 有权取代的吡唑并[1,5-A]吡啶，其制备和用作药物公开(公告)号：US09487513B2
公开(公告)日：2016-11-08
申请号：US14379844
申请日：2013-02-21
IPC分类号： C07D471/04 , C07D519/00 , C07D491/107
CPC分类号： C07D471/04 , C07D491/107 , C07D519/00
摘要： The present invention relates to new substituted pyrazolo[1,5-a]pyridine having a great affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
摘要翻译： 本发明涉及对σ受体，特别是σ-1受体以及其制备方法对包含它们的组合物具有很大亲和性的新取代的吡唑并[1,5-a]吡啶，以及它们的用途 作为药物。
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公开(公告)号：US20160310501A1
公开(公告)日：2016-10-27
申请号：US15104752
申请日：2014-12-16
IPC分类号： A61K31/5377 , A61K31/195
CPC分类号： A61K31/5377 , A61K31/195 , A61K31/197 , A61K31/415 , A61K45/06 , A61K2300/00
摘要： The invention refers to a synergistic combination comprising a Sigma ligand of general formula (I), and a Gabapentinoid, a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament, particularly for the prophylaxis and/or treatment of pain.
摘要翻译： 本发明涉及包含通式（I）的Sigma配体和加巴喷丁动物，包含所述活性物质组合的药物和所述活性物质组合在制备药物中的用途的协同组合，特别是用于预防和 /或治疗疼痛。
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![Substituted pyrazolo[3,4-d]pyrimidine compounds, their preparation and use as sigma receptors ligands](/abs-image/US/2016/03/08/US09278974B2/abs.jpg.150x150.jpg)
9.发明授权Substituted pyrazolo[3,4-d]pyrimidine compounds, their preparation and use as sigma receptors ligands 有权取代的吡唑并[3,4-d]嘧啶化合物，其制备和用作σ受体配体公开(公告)号：US09278974B2
公开(公告)日：2016-03-08
申请号：US14442816
申请日：2013-11-14
IPC分类号： C07D293/06 , C07H21/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to new substituted pyrazolo[3,4-d]pyrimidine compounds, having a great affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
摘要翻译： 本发明涉及对σ受体，特别是σ-1受体以及其制备方法对包含它们的组合物具有很大亲和性的新的取代的吡唑并[3,4-d]嘧啶化合物， 用作药物。
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10.发明申请1,2,3-TRIAZOLE-4-AMINE DERIVATIVES FOR THE TREATMENT OF SIGMA RECEPTOR RELATED DISEASES AND DISORDERS 有权用于治疗SIGMA受体相关疾病和疾病的1,2,3-三唑-4-胺衍生物公开(公告)号：US20150353510A1
公开(公告)日：2015-12-10
申请号：US14759280
申请日：2014-01-07
IPC分类号： C07D249/04 , C07F7/10 , C07D295/185 , C07D249/06 , C07D401/12
CPC分类号： C07D249/04 , C07D249/06 , C07D295/185 , C07D401/12 , C07F7/10
摘要： The present invention relates to new 1,2,3-triazole-amine derivatives, having affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments for the treatment of sigma receptor related diseases and disorders.
摘要翻译： 本发明涉及对σ受体，特别是σ-1受体以及其制备方法对包含它们的组合物具有亲和性的新的1,2,3-三唑 - 胺衍生物，以及它们作为 用于治疗σ受体相关疾病和病症的药物。
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