公开(公告)号：US10238668B2

公开(公告)日：2019-03-26

申请号：US15207694

申请日：2016-07-12

Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.

Inventor： Carlos Ramon Plata Salaman ,  Nicolas Tesson

IPC: A61K31/135 ,  A61K31/635 ,  C07C217/24 ,  C07D231/12 ,  A61K31/192 ,  C07C59/64 ,  C07C217/74 ,  A61K45/06

Abstract: The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.

公开(公告)号：US09012440B2

公开(公告)日：2015-04-21

申请号：US14066127

申请日：2013-10-29

Applicant: Laboratorios del Dr. Esteve, S.A.

Inventor： Carlos Ramon Plata Salaman ,  Nicolas Tesson

IPC: A01N43/00 ,  A61K31/33 ,  A01N33/00 ,  A61K31/13 ,  A61K31/16 ,  A61K31/192 ,  A61K31/135 ,  C07C59/64 ,  C07C217/74 ,  A61K31/137 ,  A61K31/635

CPC classification number: A61K31/635 ,  A61K9/16 ,  A61K31/135 ,  A61K31/137 ,  A61K31/192 ,  A61K45/06 ,  C07B2200/13 ,  C07C59/64 ,  C07C217/74 ,  C07C2601/14 ,  C07D231/12 ,  A61K2300/00

Abstract: The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.

Abstract translation: 本发明涉及选自NSAIDs / coxibs的曲马多和共晶体形成剂的共晶体，其制备方法及其作为药物的用途或药物制剂，特别是用于治疗疼痛。

公开(公告)号：US10245276B2

公开(公告)日：2019-04-02

申请号：US15231915

申请日：2016-08-09

Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.

Inventor： Carlos Ramon Plata Salaman ,  Nicolas Tesson

IPC: A61K31/135 ,  A61K31/635 ,  C07C217/24 ,  C07D231/12 ,  A61K31/192 ,  C07C59/64 ,  C07C217/74 ,  A61K45/06

Abstract: The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.

公开(公告)号：US09393220B2

公开(公告)日：2016-07-19

申请号：US14324448

申请日：2014-07-07

Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.

Inventor： Helmut Heinrich Buschmann ,  Lluis Sola Carandell ,  Jordi Benet Buchholz ,  Jordi Carles Ceron Bertran ,  Carlos Ramon Plata Salaman ,  Nicolas Tesson

IPC: C07C59/64 ,  C07C217/74 ,  A61K31/135 ,  A61K31/192 ,  A61K31/137 ,  A61K31/635

CPC classification number: A61K31/635 ,  A61K9/16 ,  A61K31/135 ,  A61K31/137 ,  A61K31/192 ,  A61K45/06 ,  C07B2200/13 ,  C07C59/64 ,  C07C217/74 ,  C07C2601/14 ,  C07D231/12 ,  A61K2300/00

Abstract: The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.

Abstract translation: 本发明涉及选自NSAIDs的曲马多和共晶体形成剂的共晶体，其制备方法及其作为药物的用途或药物制剂，特别是用于治疗疼痛。