公开(公告)号：US11242312B2

公开(公告)日：2022-02-08

申请号：US17051896

申请日：2019-05-03

申请人： LANDSTEINER GENMED, S.L.

发明人： Jesús Llenas Calvo ,  Miriam Royo Expósito ,  Unai Elezcano Donaire ,  Enrique Vázquez Tatay ,  Marta Melgarejo Díaz ,  Marta Isabel Barranco Gallardo ,  Eva Ma Medina Fuentes

IPC分类号： C07C235/84 ,  C07K5/02 ,  C07C237/22 ,  C07C259/06

摘要： The present invention relates to dipeptidyl ketoamide m-methoxyphenyl derivatives and their use in the treatment of diseases and conditions associated with elevated calpain activity, such as heart injury caused by infarction, ischemia with or without reperfusion, neurodegenerative disorders, malaria, diabetic nephropathy, neurotoxicity induced by HIV virus, cancer, and fibrotic diseases.