公开(公告)号：US20220226496A1

公开(公告)日：2022-07-21

申请号：US17607678

申请日：2020-04-29

申请人： LEGOCHEM BIOSCIENCES, INC.

发明人： Ho Young SONG ,  Yun-Hee PARK ,  Sang Eun CHAE ,  Ju Yuel BAEK ,  Kyung Eun PARK ,  Ju Young LEE ,  Su In LEE ,  Jeiwook CHAE ,  Chang Sun LEE ,  Yong Zu KIM

IPC分类号： A61K47/68 ,  A61K47/54 ,  A61K47/60 ,  A61K45/06

摘要： The present invention relates to a ligand-drug conjugate including a ligand; a linker that is connected to the ligand by a covalent bond and has a tris structure represented by a specific structural formula; and an active agent connected to the linker by a covalent bond. In the ligand-drug conjugate, the active agent is bound by the tris structure of the linker, and thus a greater number of active agents can be connected through one linker. Accordingly, a greater number of active agents per antibody binding can be delivered to the target cell, and the drug and/or toxin can stably reach the target cell and effectively exert the drug efficacy.