公开(公告)号：US20220226496A1

公开(公告)日：2022-07-21

申请号：US17607678

申请日：2020-04-29

Applicant: LEGOCHEM BIOSCIENCES, INC.

Inventor： Ho Young SONG ,  Yun-Hee PARK ,  Sang Eun CHAE ,  Ju Yuel BAEK ,  Kyung Eun PARK ,  Ju Young LEE ,  Su In LEE ,  Jeiwook CHAE ,  Chang Sun LEE ,  Yong Zu KIM

IPC: A61K47/68 ,  A61K47/54 ,  A61K47/60 ,  A61K45/06

Abstract: The present invention relates to a ligand-drug conjugate including a ligand; a linker that is connected to the ligand by a covalent bond and has a tris structure represented by a specific structural formula; and an active agent connected to the linker by a covalent bond. In the ligand-drug conjugate, the active agent is bound by the tris structure of the linker, and thus a greater number of active agents can be connected through one linker. Accordingly, a greater number of active agents per antibody binding can be delivered to the target cell, and the drug and/or toxin can stably reach the target cell and effectively exert the drug efficacy.

公开(公告)号：US20230310640A1

公开(公告)日：2023-10-05

申请号：US17758241

申请日：2020-12-30

Applicant: LEGOCHEM BIOSCIENCES, INC.

Inventor： Ho Young SONG ,  Yun-Hee PARK ,  Kun Jung LEE ,  Ji Hye OH ,  Sung Min KIM ,  Kyung Eun PARK ,  Yong Gyu PARK ,  Hyun Min RYU ,  Na Ra HAN ,  Chul Woong CHUNG ,  Jei Wook CHAE ,  Yong Zu KIM

IPC: A61K47/68 ,  A61K47/54 ,  A61P35/00

CPC classification number: A61K47/6871 ,  A61K47/545 ,  A61K47/549 ,  A61K47/6803 ,  A61P35/00

Abstract: The present invention relates to a pyrrolobenzodiazepine derivative compound, a conjugate of the same with a ligand, and the use of the same. The pyrrolobenzodiazepine derivative compound is more stable in plasma, is stable even in circulation, and exhibits excellent efficacy. In particular, the conjugate of the pyrrolobenzodiazepine derivative compound with a ligand has a great advantage in that it is possible to target and specifically treat proliferative disease such as cancer, maximize drug efficacy, and minimize the expression of side effects since the conjugate more stably reaches the target cell and effectively exerts drug efficacy while toxicity is greatly reduced as a linker technology that allows drugs to be easily released within cancer cells and maximize drug efficacy is incorporated.