公开(公告)号：US09345774B2

公开(公告)日：2016-05-24

申请号：US14412978

申请日：2013-07-05

Applicant: LEO PHARMA A/S

Inventor： Karsten Petersson ,  Kit Frederiksen ,  Diana Omkvist ,  Jörgen Jansson

IPC: A61K9/00 ,  A61K47/32 ,  A61K9/70 ,  A61K9/12 ,  A61K31/573 ,  A61K47/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38 ,  A61K47/44 ,  B65D83/14 ,  A61K47/22

CPC classification number: A61K31/573 ,  A61K9/0014 ,  A61K9/124 ,  A61K9/7015 ,  A61K47/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  A61K47/44 ,  B65D83/752

Abstract: A sprayable film-forming pharmaceutical composition for dermal application comprises at least one therapeutically active ingredient dissolved in a pharmaceutically acceptable propellant selected from the group consisting of dimethyl ether, diethyl ether and methylethylether, and a mixture of dimethyl ether, diethylether and methylethyl ether, and a second propellant selected from C3-5 alkanes, hydrofluoroalkanes, hydrochloroalkanes, fluoroalkanes and chlorofluoroalkanes, the propellant being present in an amount of 50-99.5% w/w of the composition, the composition further comprising a film-forming polymer, a plasticizer and an oily release-enhancing agent.

Abstract translation: 用于真皮施用的可喷雾成膜药物组合物包含溶解在选自二甲醚，二乙醚和甲基乙醚的药学上可接受的推进剂中的至少一种治疗活性成分，以及二甲醚，二乙醚和甲基乙基醚的混合物，以及 选自C3-5烷烃，氢氟烷烃，氢氯烃，氟代烷烃和氯氟烷烃的第二推进剂，推进剂的含量为组合物的50-99.5％w / w，组合物还包含成膜聚合物，增塑剂和 油性释放增强剂。

公开(公告)号：US20150157729A1

公开(公告)日：2015-06-11

申请号：US14412978

申请日：2013-07-05

Applicant: LEO PHARMA A/S

Inventor： Karsten Petersson ,  Kit Frederiksen ,  Diana Omkvist ,  Jörgen Jansson

IPC: A61K47/44 ,  A61K47/38 ,  A61K47/32 ,  A61K47/14 ,  B65D83/14 ,  A61K47/08 ,  A61K47/06 ,  A61K31/573 ,  A61K9/00 ,  A61K9/12 ,  A61K47/10

CPC classification number: A61K31/573 ,  A61K9/0014 ,  A61K9/124 ,  A61K9/7015 ,  A61K47/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  A61K47/44 ,  B65D83/752

Abstract: A sprayable film-forming pharmaceutical composition for dermal application comprises at least one therapeutically active ingredient dissolved in a pharmaceutically acceptable propellant selected from the group consisting of dimethyl ether, diethyl ether and methylethylether, and a mixture of dimethyl ether, diethylether and methylethyl ether, and a second propellant selected from C3-5 alkanes, hydrofluoroalkanes, hydrochloroalkanes, fluoroalkanes and chlorofluoroalkanes, the propellant being present in an amount of 50-99.5% w/w of the composition, the composition further comprising a film-forming polymer, a plasticizer and an oily release-enhancing agent.

Abstract translation: 用于真皮施用的可喷雾成膜药物组合物包含溶解在选自二甲醚，二乙醚和甲基乙醚的药学上可接受的推进剂中的至少一种治疗活性成分，以及二甲醚，二乙醚和甲基乙基醚的混合物，以及 选自C3-5烷烃，氢氟烷烃，氢氯烃，氟代烷烃和氯氟烷烃的第二推进剂，推进剂的含量为组合物的50-99.5％w / w，组合物还包含成膜聚合物，增塑剂和 油性释放增强剂。

公开(公告)号：US20150196646A1

公开(公告)日：2015-07-16

申请号：US14410489

申请日：2013-07-05

Applicant: LEO PHARMA A/S

Inventor： Karsten Petersson ,  Kit Frederiksen ,  Diana Omkvist ,  Jörgen Jansson

IPC: A61K47/32 ,  A61K47/22 ,  A61K47/10 ,  A61K31/573 ,  A61K47/14

CPC classification number: A61K31/573 ,  A61K9/0014 ,  A61K9/124 ,  A61K9/7015 ,  A61K47/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  A61K47/44 ,  B65D83/752

Abstract: A film-forming pharmaceutical composition for dermal application comprises at least one therapeutically active ingredient dissolved in a volatile solvent, the composition further comprising a film-forming polymer, a plasticizer and an oily release-enhancing agent. The composition is capable of forming, after application on skin and evaporation of the solvent, a continuous phase comprising the film-forming polymer and the plasticizer and a dispersed phase comprising droplets of the oily release-enhancing agent.

Abstract translation: 用于真皮施用的成膜药物组合物包含溶解在挥发性溶剂中的至少一种治疗活性成分，所述组合物还包含成膜聚合物，增塑剂和油性释放增强剂。 组合物能够在皮肤上施用和蒸发溶剂后形成包含成膜聚合物和增塑剂的连续相和包含油性释放增强剂的液滴的分散相。