Patent search ap:("LEO Pharma A/S") AND inv:"Daniel Rodriguez GREVE" Page 1

1.

发明申请
5-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-5-AZASPIRO[2.5]OCTANE-8-CARBOXYLIC ACID DERIVATIVES AS NOVEL JAK KINASE INHIBITORS 审中-公开

公开(公告)号：US20200009147A1

公开(公告)日：2020-01-09

申请号：US16483079

申请日：2018-02-01

Applicant: LEO Pharma A/S

Inventor： Mogens LARSEN , Andreas RITZEN , Bjarne NØRREMARK , Daniel Rodriguez GREVE

IPC: A61K31/519 , C07D487/04

Abstract: The present invention relates to a compound according to formula I wherein X represents NH or 0; n is an integer selected from 1-3; Y represents a bond, —C(O)O—*, —C(O)OR3—* or —C(O)NHR3—*; W is selected from the group consisting of phenyl, pyridyl, (C3-C7)cycloalkyl and 4-6 membered heterocycloalkyl; or pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention relates further to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.

2.

发明申请
SUBSTITUTED AZETIDINE DIHYDROTHIENOPYRIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS 有权

公开(公告)号：US20210079012A1

公开(公告)日：2021-03-18

申请号：US16772615

申请日：2018-12-14

Applicant: LEO Pharma A/S

Inventor： Mark ANDREWS , Daniel Rodriguez GREVE , Bjarne NØRREMARK

IPC: C07D495/04

Abstract: The present invention relates to novel substituted azetidine dihydrothienopyridines with phosphodiesterase inhibitory activity, and to their use in therapy, and to pharmaceutical compositions comprising the compounds and to methods of treating diseases with the compounds (I)

3.

发明申请
SUBSTITUTED AZETIDINE DIHYDROTHIENOPYRIMIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS 有权

公开(公告)号：US20210070769A1

公开(公告)日：2021-03-11

申请号：US16772428

申请日：2018-12-14

Applicant: LEO Pharma A/S

Inventor： Mark ANDREWS , Daniel Rodriguez GREVE , Jens LARSEN

IPC: C07D495/04

Abstract: The present invention relates to novel substituted azetidine dihydrothienopyrimidines with phosphodiesterase inhibitory activity, and to their use in therapy, and to pharmaceutical compositions comprising the compounds and to methods of treating diseases with the compounds (I).

4.

发明申请
BICYCLIC AMINES AS NOVEL JAK KINASE INHIBITORS 审中-公开

公开(公告)号：US20190382418A1

公开(公告)日：2019-12-19

申请号：US16479375

申请日：2018-01-19

Applicant: LEO Pharma A/S

Inventor： Daniel Rodriguez GREVE , Tue Heesgaard JEPSEN , Mogens LARSEN , Andreas RITZEN

IPC: C07D519/00 , A61K31/519

Abstract: The present invention relates to a compound according to formula I wherein R1 represents alkyl; n is 1 or 2; R2 is selected from the group consisting of hydrogen, cyano, —SO2Ra, —SO2NRbRc, —C(O)Rb, phenyl and 5- and 6-membered heteroaryl or pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention relates further to, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.

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