公开(公告)号：US20190382418A1

公开(公告)日：2019-12-19

申请号：US16479375

申请日：2018-01-19

Applicant: LEO Pharma A/S

Inventor： Daniel Rodriguez GREVE ,  Tue Heesgaard JEPSEN ,  Mogens LARSEN ,  Andreas RITZEN

IPC: C07D519/00 ,  A61K31/519

Abstract: The present invention relates to a compound according to formula I wherein R1 represents alkyl; n is 1 or 2; R2 is selected from the group consisting of hydrogen, cyano, —SO2Ra, —SO2NRbRc, —C(O)Rb, phenyl and 5- and 6-membered heteroaryl or pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention relates further to, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.