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公开(公告)号:US20160168096A1
公开(公告)日:2016-06-16
申请号:US14894928
申请日:2014-06-26
发明人: Young Kwan KIM , Sang Yun PARK , Hyun Woo JOO , Eun Sil CHOI
IPC分类号: C07D213/643 , C07D405/12 , C07C59/68 , C07D213/74 , C07D213/70 , C07D213/64
CPC分类号: C07D213/643 , C07C59/68 , C07C59/72 , C07C217/80 , C07C323/52 , C07C323/53 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/30 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/74 , C07D401/04 , C07D401/12 , C07D405/12 , C07D413/12
摘要: The present invention relates to biaryl derivatives of Formula 1, a method for preparing the same, a pharmaceutical composition comprising the same and use thereof. The biaryl derivatives of Formula 1 according to the present invention promote GLP-1 formation in the gastrointestinal tract and improve insulin resistance in the liver or in muscle due to anti-inflammatory action in macrophages, lipocytes, etc., and can accordingly be effectively used for preventing or treating diabetes, complications of diabetes, obesity, non-alcoholic fatty liver, steatohepatitis, osteoporosis or inflammation.
摘要翻译: 本发明涉及式1的联芳基衍生物,其制备方法,包含该化合物的药物组合物及其用途。 根据本发明的式1的联芳基衍生物促进胃肠道中的GLP-1形成,并且由于巨噬细胞,脂肪细胞等中的抗炎作用而改善肝脏或肌肉中的胰岛素抵抗,因此可以有效地使用 用于预防或治疗糖尿病,糖尿病并发症,肥胖症,非酒精性脂肪肝,脂肪性肝炎,骨质疏松症或炎症。