公开(公告)号：US20160024470A1

公开(公告)日：2016-01-28

申请号：US14806403

申请日：2015-07-22

Applicant: LIFE TECHNOLOGIES AS

Inventor： Tanja AARVAK ,  Anne-Marie RASMUSSEN ,  Gunnar KVALHEIM ,  Walter Gabriell Borelli PIEDRAS ,  Anne BRUNSVIG

IPC: C12N5/0783 ,  A61K35/17

CPC classification number: C12N5/0637 ,  A61K31/12 ,  A61K35/17 ,  A61K2035/122 ,  C12N5/0636 ,  C12N2501/04 ,  C12N2501/2302 ,  C12N2501/2304 ,  C12N2501/998 ,  C12N2501/999

Abstract: Methods are disclosed for the generation of immunosuppressive regulatory T cells. The methods can include contacting a population of CD4+CD25− T cells with a T cell receptor (TCR)/CD3 activator, a TCR co-stimulator activator, and rapamycin. Kits for the generation of immunosuppressive regulatory T cells, methods of use, and cell populations are also disclosed.

Abstract translation: 公开了用于产生免疫抑制性调节性T细胞的方法。 所述方法可以包括使CD4 + CD25-T细胞群与T细胞受体（TCR）/ CD3激活剂，TCR共刺激因子激活剂和雷帕霉素接触。 还公开了用于产生免疫抑制性调节性T细胞，使用方法和细胞群的试剂盒。

公开(公告)号：US20130164312A1

公开(公告)日：2013-06-27

申请号：US13689530

申请日：2012-11-29

Applicant: Life Technologies AS

Inventor： Tanja AARVAK ,  Anne-Marie RASMUSSEN ,  Gunnar KVALHEIM ,  Walter Gabriell Borelli PIEDRAS ,  Anne BRUNSVIG

IPC: C12N5/0783

CPC classification number: C12N5/0637 ,  A61K31/12 ,  A61K35/17 ,  A61K2035/122 ,  C12N5/0636 ,  C12N2501/04 ,  C12N2501/2302 ,  C12N2501/2304 ,  C12N2501/998 ,  C12N2501/999

Abstract: Methods are disclosed for the generation of immunosuppressive regulatory T cells. The methods can include contacting a population of CD4+CD25− T cells with a T cell receptor (TCR)/CD3 activator, a TCR co-stimulator activator, and rapamycin. Kits for the generation of immunosuppressive regulatory T cells, methods of use, and cell populations are also disclosed.

Abstract translation: 公开了用于产生免疫抑制性调节性T细胞的方法。 所述方法可以包括使CD4 + CD25-T细胞群与T细胞受体（TCR）/ CD3激活剂，TCR共刺激因子激活剂和雷帕霉素接触。 还公开了用于产生免疫抑制性调节性T细胞，使用方法和细胞群的试剂盒。

公开(公告)号：US20190071640A1

公开(公告)日：2019-03-07

申请号：US16057274

申请日：2018-08-07

Applicant: LIFE TECHNOLOGIES AS

Inventor： Tanja AARVAK ,  Anne-Marie RASMUSSEN ,  Gunnar KVALHEIM ,  Walter Gabriell Borelli PIEDRAS ,  Anne BRUNSVIG

IPC: C12N5/0783 ,  A61K35/17 ,  A61K31/12

Abstract: Methods are disclosed for the generation of immunosuppressive regulatory T cells. The methods can include contacting a population of CD4+CD25− T cells with a T cell receptor (TCR)/CD3 activator, a TCR co-stimulator activator, and rapamycin. Kits for the generation of immunosuppressive regulatory T cells, methods of use, and cell populations are also disclosed.

公开(公告)号：US20220275331A1

公开(公告)日：2022-09-01

申请号：US17578172

申请日：2022-01-18

Applicant: LIFE TECHNOLOGIES AS

Inventor： Hilde ALMAASBAK ,  Tanja AARVAK ,  Kerstin BERNSTROEM ,  Oystein AAMELLEM

IPC: C12N5/0783

Abstract: This invention relates, inter alia, to compositions of expanded T cell populations, methods for the expansion of T cell populations and methods for using such populations of cells. In some aspects, the invention relates to compositions and methods for the selective expansion of T cell subpopulations present in mixed T cell populations, as well as T cell subpopulations produced by methods for the invention.

公开(公告)号：US20190062706A1

公开(公告)日：2019-02-28

申请号：US15771821

申请日：2016-10-27

Applicant: LIFE TECHNOLOGIES AS

Inventor： Hilde ALMAASBAK ,  Tanja AARVAK ,  Kerstin BERNSTROEM ,  Oystein AAMELLEM

IPC: C12N5/0783

Abstract: This invention relates, inter alia, to compositions of expanded T cell populations, methods for the expansion of T cell populations and methods for using such populations of cells. In some aspects, the invention relates to compositions and methods for the selective expansion of T cell subpopulations present in mixed T cell populations, as well as T cell subpopulations produced by methods for the invention.