公开(公告)号：US20170103162A1

公开(公告)日：2017-04-13

申请号：US15333025

申请日：2016-10-24

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Harrison Leong ,  Catalin Barbacioru ,  Gordon Janaway

IPC: G06F19/22 ,  G06F19/24 ,  C12Q1/68 ,  G06N7/00

CPC classification number: G16B30/00 ,  C12Q1/6827 ,  G06N7/005 ,  G16B20/00 ,  G16B40/00

Abstract: Methods for the determination of a copy number of a target genomic sequence; either a target gene or genomic sequence of interest, in a biological sample are described. Various methods utilize a model drawn from a probability density function (PDF) for the assignment of a copy number of a target genomic sequence in a biological sample. Additionally, the methods provide for the determination of a confidence value for a copy number assigned to a sample based on attributes of the sample data. Accordingly, the various methods for the determination of a copy number provide the end user with significant information for the evaluation of a copy number of a target genomic sequence; either a gene or genomic sequence of interest.