公开(公告)号：US20240392041A1

公开(公告)日：2024-11-28

申请号：US18772605

申请日：2024-07-15

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Brian Agnew ,  Robert Aggeler ,  Rolando Brawer

IPC: C07K16/46 ,  A61K9/00 ,  A61K47/60 ,  A61K47/68 ,  A61K47/69 ,  C12N9/24 ,  C12N15/113 ,  C12P21/00 ,  G01N33/68

Abstract: Methods are provided for making bispecific antibodies and antibody conjugates comprising site-specifically cross-linking two or more antibodies, antibody fragments or Fc-fusion proteins. Also provided are compositions and uses for the bispecific antibodies and antibody conjugates. The bispecific antibodies may be used to treat a disease or condition. Also provided are methods for site-specifically conjugating a liposome, an mRNA or an siRNA to an antibody, and uses of the antibody-conjugated liposome, mRNA or siRNA.