公开(公告)号：US20240021272A1

公开(公告)日：2024-01-18

申请号：US18330737

申请日：2023-06-07

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Fiona HYLAND ,  Eric TSUNG ,  Vasisht TADIGOTLA ,  Zheng ZHANG ,  Dumitru BRINZA ,  Onur SAKARYA ,  Xing XU

IPC: G16B30/10 ,  G16B30/00

CPC classification number: G16B30/10 ,  G16B30/00

Abstract: Systems and method for determining variants can receive mapped reads, and call variants. In embodiments, flow space information for the reads can be aligned to a flow space representation of a corresponding portion of the reference. Reads spanning a position with a potential variant can be grouped and a score can be calculated for the variant. Based on the scores, a list of probable variants can be provided. In various embodiments, low frequency variants can be identified where multiple potential variants are present at a position.

公开(公告)号：US20200027527A1

公开(公告)日：2020-01-23

申请号：US16530015

申请日：2019-08-02

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Fiona Hyland ,  Eric TSUNG ,  Vasisht TADIGOTLA ,  Zheng ZHANG ,  Dumitru BRINZA ,  Onur SAKARYA ,  Xing XU

IPC: G16B30/00

Abstract: Systems and method for determining variants can receive mapped reads, and call variants. In embodiments, flow space information for the reads can be aligned to a flow space representation of a corresponding portion of the reference. Reads spanning a position with a potential variant can be grouped and a score can be calculated for the variant. Based on the scores, a list of probable variants can be provided. In various embodiments, low frequency variants can be identified where multiple potential variants are present at a position.