公开(公告)号：US20160311888A1

公开(公告)日：2016-10-27

申请号：US15206063

申请日：2016-07-08

Applicant: LIGAND PHARMACEUTICALS INCORPORATED

Inventor： Roland Buelow

IPC: C07K16/00 ,  A01K67/027 ,  C12N15/85 ,  C12N5/075

CPC classification number: C07K16/00 ,  A01K67/0276 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2267/01 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/76 ,  C12N5/0609 ,  C12N9/22 ,  C12N15/8509 ,  C12N2015/8518 ,  C12N2510/00

Abstract: The invention relates to transgenic animals lacking endogenous Ig and capable of producing transgenic antibodies, as well as methods of making the same. The invention further relates to methods for producing transgenic antibodies in such animals, and transgenic antibodies so produced.