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公开(公告)号:US20240307388A1
公开(公告)日:2024-09-19
申请号:US18501268
申请日:2023-11-03
发明人: Nigel R.A Beeley , John Gordon Foulkes , Kieran George Mooney , Charles Rodney Greenaway Evans , Keith Arthur Johnson , Howard G. Welgus , Celia P. Jenkinson , James R. Hauske
IPC分类号: A61K31/501 , A61K9/00 , A61K9/06 , A61K31/40 , A61K31/4439 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/18 , A61K47/32
CPC分类号: A61K31/501 , A61K31/40 , A61K31/4439 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/183 , A61K47/32 , A61K9/0014 , A61K9/06 , A61K45/06
摘要: Pharmaceutical carriers which provide an environment of physical and chemical stability comprising a therapeutically effective amount of an active pharmaceutical ingredient (API) compound of structure I, one or more antioxidants, one or more chelators and a vehicle base comprising water and one or more pharmaceutically acceptable non-aqueous solvents, one or more absorption enhancers, one or more gelling agents and one or more pH buffering agents are described.