公开(公告)号：US20210000963A1

公开(公告)日：2021-01-07

申请号：US16977018

申请日：2018-03-01

申请人： LTS LOHMANN THERAPIE-SYSTEME AG

发明人： Thomas HILLE ,  Gabriel WAUER ,  Frank SEIBERTZ

IPC分类号： A61K47/46 ,  A61K9/00 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/465 ,  A61K47/32 ,  A61K47/38 ,  A61K47/10 ,  A61K47/02 ,  A61K47/26 ,  A61K47/18

摘要： Disclosed are stable dosage forms for oral administration of active pharmaceutical ingredients in which any unpleasant taste sensation, caused by release of the active pharmaceutical ingredient and/or of the excipients in the oral and pharyngeal cavity of the patient, is masked by the use of theobromine-free cocoa.

公开(公告)号：US20200246276A1

公开(公告)日：2020-08-06

申请号：US16641741

申请日：2018-08-31

申请人： LTS LOHMANN THERAPIE-SYSTEME AG

发明人： Gabriel WAUER ,  Frank SEIBERTZ

IPC分类号： A61K9/70 ,  A61K31/196 ,  A61K47/12 ,  A61K31/485 ,  A61K47/44 ,  A61P29/00 ,  A61K47/34

摘要： The present invention relates to a transdermal therapeutic system (TTS) comprising an active agent-containing layer structure comprising A) a backing layer and B) a biphasic matrix layer, the biphasic matrix layer having a) a continuous, outer phase having a composition comprising 70 to 100% by weight of at least one polymer, b) a discontinuous, inner phase having a composition comprising the active agent and a dissolver for the active agent in amount sufficient so that the active agent forms a solution with the dissolver in the inner phase and c) an emulsifier in an amount of 0.1 to 20% by weight based on the biphasic matrix layer, processes of manufacture and uses thereof, corresponding methods of treatments therewith.

公开(公告)号：US20240285771A1

公开(公告)日：2024-08-29

申请号：US18692408

申请日：2022-09-06

申请人： LTS Lohmann Therapie-Systeme AG

发明人： Frank SEIBERTZ ,  Marius BAUER ,  Marlene FUHRMANN ,  Michael LINN ,  Marco EMGENBROICH

IPC分类号： A61K47/32 ,  A61K9/00 ,  A61K31/135 ,  A61K31/57 ,  A61K47/10 ,  A61K47/26

CPC分类号： A61K47/32 ,  A61K9/006 ,  A61K31/135 ,  A61K31/57 ,  A61K47/10 ,  A61K47/26

摘要： The invention relates to an oral thin film comprising at least one matrix layer, wherein the at least one matrix layer comprises at least one polyvinyl alcohol having a low average molecular weight and at least one polyvinyl alcohol having a high average molecular weight and at least one pharmaceutical active substance. The invention also relates to the use of the oral thin film as a medicine.

公开(公告)号：US20210161832A1

公开(公告)日：2021-06-03

申请号：US17048036

申请日：2019-04-11

申请人： LTS LOHMANN THERAPIE-SYSTEME AG

发明人： Gabriel WAUER ,  Frank SEIBERTZ

IPC分类号： A61K9/70 ,  A61K31/4748 ,  A61K31/27 ,  A61F13/02 ,  A61K47/32 ,  A61K47/14

摘要： The present invention relates to transdermal therapeutic systems (TTS) for the transdermal administration of solifenacin.