公开(公告)号：US20210247291A1

公开(公告)日：2021-08-12

申请号：US17052061

申请日：2019-05-02

Applicant: LUMICKS TECHNOLOGIES B.V.

Inventor： Gijs Jan Lodewijk WUITE ,  Raya SORKIN ,  Douwe KAMSMA ,  Gerrit SITTERS ,  Erwin Johannes Gerard PETERMAN ,  Giulia BERGAMASCHI ,  Mattijs DE GROOT

IPC: G01N15/14 ,  B01L3/00

Abstract: A method for probing mechanical properties of cellular bodies includes: providing a plurality of particles in a fluid medium contained in a holding space of a sample holder, each of the plurality of particle being attached to a cellular body; generating a resonant bulk acoustic wave in the holding space, the resonant bulk acoustic wave exerting an acoustic force on each of the plurality of particles, each of the plurality of particles having an acoustic contrast factor and a size, the acoustic contrast factor and the size being selected such that the force exerted on a particle is larger than the force exerted on the cellular body to which the particle is attached; measuring a displacement of a particle in response to the exertion of the force on the particle, the measured displacement being associated with a mechanical property of the cellular body attached to the particle.