公开(公告)号：US20230140054A1

公开(公告)日：2023-05-04

申请号：US17792298

申请日：2021-01-17

申请人： Lupin Limited

发明人： Rajender Kumar KAMBOJ ,  Kamlesh Jyotindra PADIYA ,  Kamalakannan PRABAKARAN ,  Kumar Ram NAIK ,  Bhavani Shankar RAJESH ,  Ganpati Powar RAJENDRA ,  Subhash Ingawale SACHIN ,  Dattatray Karche AMIT ,  Shankar Dange SANTOSHKUMAR ,  Barve SITARAM RAMBHAU

IPC分类号： C07D311/58

摘要： This disclosure describes an economical and scalable method and process to synthesize the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts therefor. Uses of said intermediates for synthesis of compounds which may be intermediates to the synthesis of 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid are also described herein.

公开(公告)号：US20230025246A1

公开(公告)日：2023-01-26

申请号：US17778282

申请日：2020-11-18

申请人： LUPIN LIMITED

发明人： Rajender Kumar KAMBOJ ,  Shaji George KOCHUMALAYIL ,  Spinvin VENUGOPAL ,  Kamlesh Jyotindra PADIYA ,  Prabakaran KAMALAKANNAN ,  Kumar Ram NAIK ,  Sachin Subhash INGAWALE ,  Bhavani Shankar RAJESH ,  Rajendra Ganpati POWAR

IPC分类号： C07D311/58

摘要： A process for manufacturing substituted chroman compounds in an economically scalable manner, without the use of pyrophoric reagents. Also disclosed herein are chroman compound synthesis routes that do not include column chromatography purification steps. The disclosure also relates to the intermediates used in the synthesis. In particular, the disclosure relates to the synthesis of the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts thereof.