公开(公告)号：US20230025246A1

公开(公告)日：2023-01-26

申请号：US17778282

申请日：2020-11-18

申请人： LUPIN LIMITED

发明人： Rajender Kumar KAMBOJ ,  Shaji George KOCHUMALAYIL ,  Spinvin VENUGOPAL ,  Kamlesh Jyotindra PADIYA ,  Prabakaran KAMALAKANNAN ,  Kumar Ram NAIK ,  Sachin Subhash INGAWALE ,  Bhavani Shankar RAJESH ,  Rajendra Ganpati POWAR

IPC分类号： C07D311/58

摘要： A process for manufacturing substituted chroman compounds in an economically scalable manner, without the use of pyrophoric reagents. Also disclosed herein are chroman compound synthesis routes that do not include column chromatography purification steps. The disclosure also relates to the intermediates used in the synthesis. In particular, the disclosure relates to the synthesis of the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts thereof.