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公开(公告)号：US20240067828A1
公开(公告)日：2024-02-29
申请号：US18270477
申请日：2021-11-29
IPC分类号： C09C1/02
CPC分类号： C09C1/021 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/52 , C01P2006/40
摘要： The disclosure relates to lipid-coated calcium carbonate nanoparticles, said nanoparticles comprising an outer layer and a core being calcium carbonate nanoparticle, wherein said core is vaterite, proto-vaterite, or amorphous calcium carbonate as determined by X-Ray diffraction, wherein said core is at least partially coated with one or more amphiphilic compounds each having one hydrophilic head and at least one hydrophobic tail, remarkable in that the hydrophilic heads are negatively charged and form the outer layer of the nanoparticles, in that the nanoparticles have a surface charge having a ζ-potential below 0 mV as determined by micro-electrophoretic light scattering technology and in that said one or more amphiphilic compounds are PEG-free. The disclosure also relates to methods for forming such nanoparticles, for modulating the electrical charge of such nanoparticles as well as to the uses of such nanoparticles.
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公开(公告)号：US20240002247A1
公开(公告)日：2024-01-04
申请号：US18270478
申请日：2021-11-29
IPC分类号： C01F11/18
CPC分类号： C01F11/185 , C01P2004/32 , C01P2004/04 , C01P2004/64 , C01P2002/02 , C01P2004/52
摘要： The disclosure relates to core-shell nanoparticle, the nanoparticle comprising a core being one or more selected from vaterite, proto-vaterite, and amorphous calcium carbonate as determined by X-Ray diffraction, remarkable in that the nanoparticle further comprises a shell of polyphenol, wherein said polyphenol is selected to be insoluble in water, to show a pH ranging from 5 to 9 when measured in a solution of one or more polar solvents and water at a concentration of 10 wt. % based on the total weight of said solution and wherein said polyphenol is at least partially soluble in said one or more polar solvents. A method for forming such nanoparticle as well as their use and the use of polyphenol as shell of shell-core nanoparticle is also described.
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